Uric Acid/ HDL Ratio as a Marker of Disease in Coronary Artery Ectasia Versus Normal Coronaries

Authors

  • Maida Anwar Department of Adult Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University Of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Asif Nadeem Department of Adult Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University Of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Muhammad Bilal Siddique Department of Adult Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University Of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Fahad Khan Toru Department of Adult Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University Of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Asma Zafar Khawaja Department of Adult Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University Of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Sarwat Paiker Malik Department of Adult Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University Of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Javeria Kamran Department of Adult Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University Of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Naseem Azad Department of Adult Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University Of Medical Sciences (NUMS) Rawalpindi, Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74iSUPPL-1.10594

Keywords:

Coronary artery ectasia, Unobstructed coronaries, Uric Acid/HDL Ratio

Abstract

Objective: To determine the strength of association of raised uric acid/ High-Density Lipoprotein ratio in patients with Coronary Artery Ectasia versus normal coronaries.

Study Design: Analytical Cross-sectional study.

Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Diseases, Rawalpindi, Dec 2022 to May 2023

Methodology: Total n=146 patients aged between 20-90 years of both gender, with chest pain who had CAE or unobstructed coronaries on coronary angiography, and normal heart structure and valvular function were included. Patients were divided into two groups: those with Coronary Artery Ectasia (Group-I) and those without Coronary Artery Ectasia (Group-II). Serum uric acid and High-Density Lipoprotein level were measured for each patient and their ratio was calculated. Qualitative variables were compared across groups using the Chi-square test/Fischer Exact test, while quantitative variables were compared using the independent samples t-test. Univariate and multivariate logistic regression analysis was used to predict the odds ratio to show association between predictors and outcome (Coronary Artery Ectasia) and p<0.05 was considered as statistically significant

Results: Study sample n=146 had mean age of 52.83 ± 9.67 years, comprised of 113(77.4%) males and 33(22.6%) females. Uric acid to HDL ratio above 0.12 had an adjusted odds ratio (aOR) of 9.3 (CI 95% 3.3–26.0) for having Coronary artery ectasia (p<0.001). Males and age of 60 years or greater were also associated with an increased odds, with (aORs) of .....

Conclusion: Uric acid/HDL ratio is a useful variable in predicting odds of coronary artery ectasia in patients with chest pain.

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Published

30-05-2024

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Original Articles

How to Cite

1.
Anwar M, Nadeem A, Siddique MB, Toru FK, Khawaja AZ, Malik SP, et al. Uric Acid/ HDL Ratio as a Marker of Disease in Coronary Artery Ectasia Versus Normal Coronaries. Pak Armed Forces Med J [Internet]. 2024 May 30 [cited 2024 Jun. 16];74(SUPPL-1):S1-S5. Available from: https://pafmj.org/PAFMJ/article/view/10594