Comparison of Pretreatment with Dexmedetomidine and Metoprolol on Attenuation of Hemodynamic Parameters and Emergence During Electroconvulsive Therapy

Authors

  • Khalid Mahmood Department of Anesthesia, Combined Military Hospital Sialkot /National University of Medical Sciences (NUMS) Pakistan
  • Mohsin Saleem Department of Anesthesia, Combined Military Hospital Sialkot /National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Ali Abbas Department of Anesthesia, Combined Military Hospital Pano Aqil /National University of Medical Sciences (NUMS) Pakistan
  • Bilal Yasin Department of Anesthesia, Combined Military Hospital Okara /National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Saeed Department of Anesthesia, Combined Military Hospital Nowshera /National University of Medical Sciences (NUMS) Pakistan
  • Saleha Sarfraz Department of Anesthesia, Combined Military Hospital Sialkot /National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i4.10399

Keywords:

Agitation, Attenuation, Dexmedetomidine, Metoprolol

Abstract

Objective: To evaluate the effects of Dexmedetomidine and Metoprolol as a pretreatment regimen on hemodynamic parameters and emergence during ECT.

Study Design: Randomized controlled trial (ANZCTR Trial Id: ACTRN12623000539639)

Place and Duration of Study: Department of Anesthesia, CMH, Sialkot, Pakistan, from January 2021 to April 2022.

Methodology: All patients undergoing ECT at CMH were enrolled in this prospective study using a convenient sampling method and divided into three groups. The C Group included subjects not pretreated with any medication. Group-D received an injection of Dexmedetomidine 0.5 μg/kg diluted in 10 mL NaCl, infused intravenously over 10 minutes. Group-M received an injection of Metoprolol 1 mg diluted in 10 mL NaCl, infused over 2 minutes during preoxygenation. Heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were recorded at baseline, then documented after drug administration at various time intervals

Results: This study performed statistical comparisons of heart rate, blood pressure, and post-procedure recovery parameters among three groups (Group-C, Group-D, and Group-M). Significant differences were found in heart rate, with Group-D and Group-M displaying significantly lower heart rates than Group-C at various time points after the intervention (p<0.001). Additionally, Group-D had significantly higher systolic blood pressure than both Group-C and Group-M after the intervention (p<0.001). Conversely, Group-M showed significantly lower diastolic blood pressure compared to Group-C and Group-D (p<0.05). 

Conclusion: Metoprolol at a dose of 1 mg or Dexmedetomidine administered intravenously at a dose of 0.5 µg/kg are both effective methods for attenuating hemodynamic parameters during ECT.  .....

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Published

30-08-2025

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Original Articles

How to Cite

1.
Mahmood K, Saleem M, Abbas MA, Yasin B, Saeed M, Sarfraz S. Comparison of Pretreatment with Dexmedetomidine and Metoprolol on Attenuation of Hemodynamic Parameters and Emergence During Electroconvulsive Therapy. Pak Armed Forces Med J [Internet]. 2025 Aug. 30 [cited 2025 Oct. 7];75(4):762-7. Available from: https://pafmj.org/PAFMJ/article/view/10399