Analgesic Effects  of Magnesium Sulphate In Patients Undergoing Laparoscopic Cholecystectom

Talha Yaseen; Syed Ali Mazhar Rizvi; Khalid Mahmood; Usman Eijaz Malik; Majid Aziz; Abid Khan

doi:10.51253/pafmj.v74iSUPPL-2.10322

Authors

Talha Yaseen Department of Anaesthesia, Pak Emirates Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Syed Ali Mazhar Rizvi Department of Anaesthesia, Pak Emirates Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Khalid Mahmood Department of Anaesthesia, Combined Military Hospital Sialkot /National University of Medical Sciences (NUMS) Pakistan
Usman Eijaz Malik Department of Anaesthesia, Pak Emirates Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Majid Aziz Department of Surgery, Pak Emirates Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Abid Khan Department of Anaesthesia, Pak Emirates Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74iSUPPL-2.10322

Keywords:

Gallbladder surgery, Laparoscopic cholecystectomy, Magnesium sulphate

Abstract

Objective: To assess the effectiveness of intraoperative administration of MgSO4 in achieving satisfactory postoperative pain relief following laparoscopic surgery.

Study Design: Quasi-experimental research.

Place and Duration of Study: Combined Military Hospital, Rawalpindi Pakistan, Apr to Sep 2021.

Methodology: A total of 200 patients gave their informed consent before being split into two groups of 100. Patients were given Tablet Alprazolam 0.25mg and Omeprazole 20mg the night before surgery and again on the morning of surgery, and were asked for NPO for 8 hours before to surgery. Group 1 got 50 mg/kg of magnesium sulphate diluted in 250 ml of isotonic 0.9% normal saline intravenously during surgery, while Group 2 received the same volume of isotonic 0.9% normal saline.

Results: Administering intravenous magnesium sulphate at an intravenous dose of 50 milligrams per kilogram of body weight before laryngoscopy and intubation significantly reduces the need for post-operative pain medication by reducing post-operative pain and delaying its onset. Additionally, it reduces the amount of pain medication required after surgery. Therefore, overall, pretreatment with magnesium sulphate has a significant impact on post-operative pain management.

Conclusion: Magnesium sulphate is an excellent analgesic for people undergoing laparoscopic cholecystectomy.

Downloads

Download data is not yet available.

References

Ali HSM, Gad GS, Fayed HM. A comparative study of clonidine and magnesium sulfate premedication on perioperative hormonal stress responses, hemodynamic stability and postoperative analgesia in patients with gallbladder diseases undergoing laparoscopic cholecystectomy. A randomized, double-blind, controlled study, Egypt J Anaesth 2022; 38(1) : 108-115. doi: 10.1080/11101849.2022.2031546

Morel V, Joly D, Villatte C, Pereira B, Pickering G. Preventive effect of oral magnesium in postmastectomy pain: protocol for a randomised, double-blind, controlled clinical trial. BMJ Open 2018 ; 8(9): e017986. doi: 10.1136/bmjopen-2017-017986.

Noah L, Morel V, Bertin C, Pouteau E, Macian N, Dualé C, et al. Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study. Nutrients. 2022 ; 14(9): 1863. doi: 10.3390/nu14091863.

Morel V, Pickering ME, Goubayon J, Djobo M, Macian N, Pickering G. Magnesium for Pain Treatment in 2021? State of the Art. Nutrients 2021; 13(5): 1397. doi: 10.3390/nu13051397.

Mahajan L, Kaur M, Gupta R. Attenuation of the pressor responses to laryngoscopy and endotracheal intubation with intravenous dexmedetomidine versus magnesium sulphate under bispectral index-controlled anaesthesia:A placebo-controlled prospective randomized trial. Indian J Anaesth. 2018; 62(5): 337–343.

Soleimanpour H, Imani F, Dolati S, Soleimanpour M, Shahsavarinia K. Management of pain using magnesium sulphate: a narrative review. Postgraduate Medicine 2022; 134(3): 260-266, doi: 10.1080/00325481.2022.2035092.

Wren AA, Ross AC, and D’Souza G. Multidisciplinary pain management for pediatric patients with acute and chronic pain: a foundational treatment approach when prescribing opioids. Children (Basel). 2019; 6(2): 33.

Sadir S, Tabassum S, Emad S, Liaquat L, Batool Z, Madiha S, et al. Neurobehavioral and biochemical effects of magnesium chloride (MgCl2), magnesium sulphate (MgSO4) and magnesium-L-threonate (MgT) supplementation in rats: A dose dependent comparative study. Pak J Pharm Sci. 2019 ; 32(1(Supplementary)): 277-283.

Tseliou V, Knaus T, Vilím J, Masman MF, Mutti FG. Kinetic Resolution of Racemic Primary Amines Using Geobacillus stearothermophilus Amine Dehydrogenase Variant. ChemCatChem. 2020 Apr 20; 12(8): 2184-2188. doi: 10.1002/cctc.201902085.

Park R, Ho AM, Pickering G, Arendt-Nielsen L, Mohiuddin M, Gilron I. Efficacy and Safety of Magnesium for the Management of Chronic Pain in Adults: A Systematic Review. Anesth Analg. 2020 ; 131(3): 764-775. doi: 10.1213/ANE.0000000000004673.

Pickering G, Pereira B, Morel V, Corriger A, Giron F, Marcaillou F, et al. Ketamine and Magnesium for Refractory Neuropathic Pain: A Randomized, Double-blind, Crossover Trial. Anesthesiology 2020; 133(1): 154-164. doi: 10.1097/ALN.0000000000003345.

Tully J, Jung JW, and Patel A. Utilization of intravenous lidocaine infusion for the treatment of refractory chronic pain. Anesth Pain Med. 2020; 10(6): 1–9. doi:https://doi.org/10.5812/aapm.112290.

Kulkarni JV, Patil S, and Sonawane R. Intravenous magnesium sulphate and lignocaine in management of trigeminal neuralgia IP Indian J Immunol Respir Med. 2020; 5(1): 68–71. doi:10.18231/j.ijirm.2020.015.

Maleki Verki M, Porozan S, Motamed H, Fahimi MA, Aryan A. Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study. Am J Emerg Med 2019; 37(6): 1033-1036. doi: 10.1016/j.ajem.2018.08.040.

Tsaousi G, Nikopoulou A, Pezikoglou I, Birba V, Grosomanidis V. Implementation of magnesium sulphate as an adjunct to multimodal analgesic approach for perioperative pain control in lumbar laminectomy surgery: A randomized placebo-controlled clinical trial. Clin Neurol Neurosurg. 2020; 197: 106091. doi: 10.1016/j.clineuro.2020.106091.

Chen C, and Tao R. The impact of magnesium sulfate on pain control after laparoscopic cholecystectomy: a meta-analysis of randomized controlled studies. Surg Laparosc Endosc Percutan Tech. 2018; 28(6): 349–353.

Kido K, Katagiri N, Kawana H, Sugino S, Konno D, Suzuki J, et al. Effects of magnesium sulfate administration in attenuating chronic postsurgical pain in rats. Biochem Biophys Res Commun 2021; 534: 395-400. doi: 10.1016/j.bbrc.2020.11.069.

Abd Elrahman TN, Youssry MA. The impact of single low dose IV magnesium sulphate adjuvant to ultrasound guided transverses abdominis plain block for control of postcesarean pain. Open J Obst Gynecol. 2017; 7(3): 269–280.