HISTOPATHOLOGICAL ANALYSIS OF GASTRIC MUCOSAL BIOPSIES IN NON ULCER DYSPEPSIA

Gastric Mucosal Biopsies in Non Ulcer Dyspepsia

Abstract

Objective: To find out the pattern of gastric mucosal histopathological findings in gastric biopsies of patients with non ulcer dyspepsia.
Study Design: Prospective descriptive study.
Place and Duration of Study: Histopathology department Combined Military Hospital (CMH) Kharian Pakistan from Jan to Dec 2015.
Material and Methods: One hundred patients presenting at outpatient gastroenterology department with dyspepsia having no endoscopic lesion were included in the study. Two gastric mucosal biopsies from antrum and two from corpus were taken. The specimens were processed and examined histologically to see the changes.
Results: Gastric biopsies of 100 patients including 65 males and 35 females presenting with non ulcer dyspepsia were studied. Most of the patients were between the age group of 31–50 years. Histological examination of gastric biopsies revealed 70% of patients having histological features of gastritis, while 30% having no significant histological finding. Chronic inflammation was seen in 70 cases (70%), activity in 15 cases (15%), glandular atrophy in 2 cases (2%) and intestinal metaplasia in 2 cases (2%). H.Pylori were identified in 25 cases (25%) based on haematoxylin and eosin (H & E) staining and modified giemsa staining.
Conclusion: Most the cases of non ulcer dyspepsia show histological evidence of gastritis, however a significant number of patients showed no gastric mucosal histological abnormality. A significantly low frequency of H. Pylori in gastric biopsies noted in non ulcer dyspepsia cases may be due to more frequent use of antibiotics and acid suppressant drugs used by general practitioners at some stage of disease.