Correlation of Disease Severity with High-Resolution Computed Tomography (HRCT) Severity Scores in COVID-19 Patients - A Cross-Sectional Study
DOI:
https://doi.org/10.51253/pafmj.v74i2.10193Keywords:
COVID-19, Disease Severity, High resolution computed tomography (HRCT) severity scoreAbstract
Objective: To determine the relationship of High-Resolution Computed Tomography Chest Severity Scores with disease
severity in COVID-19 patients.
Study Design: Cross-sectional study.
Place and Duration of Study: Pak-Emirates Military Hospital, Rawalpindi Pakistan, from Oct to Dec 2021.
Methodology: The study included 173 symptomatic patients with positive COVID polymerase chain reaction. All patients
underwent high-resolution computed tomography chest scans and were given severity scores (from 0 to 40) based on the
number of lung segments involved. Disease severity was assessed based on oxygen saturation at room air, C-reactive protein
levels, and morality on the 21st day. High-resolution chest computed tomography scores were compared with parameters of
disease severity.
Results: Out of a total of 173 patients, 139(80%) were male, and 34(20%) were female, with a mean age of 62.79±13.87 years (17-
92 years). Chest computed tomography severity scores were positively correlated with C-reactive protein levels and mortality
on the 21st day (p<0.001). Oxygen saturation at room air decreased with increased involvement in chest scans.
Conclusion: Our data suggested that high-resolution computed tomography scores are highly correlated with disease severity
and patient outcomes, particularly mortality, in Coronavirus patients
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References
Özel M, Aslan A, Araç S. Use of the COVID-19 Reporting and
Data System (CO-RADS) classification and chest computed
tomography involvement score (CT-IS) in COVID-19
pneumonia. Radiol Med 2021; 126(5): 679-687.
https://doi.org/10.1007/s11547-021-01335-x
Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical
Characteristics of Coronavirus Disease 2019 in China. N Eng J
Med 2020; 382(18): 1708–1720.
https://doi.org/10.1056/NEJMoa2002032
Deng Y, Liu W, Liu K, Fang YY, Shang J, Zhou L, et al. Clinical
characteristics of fatal and recovered cases of coronavirus
disease 2019 in Wuhan, China: a retrospective study. Chin Med J
5; 133(11): 1261.
https://doi.org/10.1097/CM9.0000000000000824
Quirch M, Lee J, Rehman S. Hazards of the Cytokine Storm and
Cytokine-Targeted Therapy in Patients With COVID-19: Review.
J Med Internet Res 2020; 22(8): e20193.
Lieveld AWE, Azijli K, Teunissen BP, van Haaften RM, Kootte
RS, van den-Berk IAH, et al. Chest CT in COVID-19 at the ED:
Validation of the COVID-19 Reporting and Data System (CORADS) and CT Severity Score: A Prospective, Multicenter,
Observational Study. Chest 2021; 159(3): 1126–1135.
https://doi.org/10.1016/j.chest.2020.11.026
Abbas S, Hayat A, Majeed N, Jaffar S, Asghar J, Ali S, et al.
Comparison Of Inflammatory Markers With Different Levels Of
Severity Of COVID-19 Disease. Pak Armed Forces Med J 2020;
(2): S455-458.
Adil M, Baig ZF, Amir M, Chatha SS, Habib A, Majid M, et al.
Neutrophil To Lymphocyte Ratio Vs Platelets To Lymphocyte
Ratio: Biomarkers To Predict Severity Of Disease And Their
Comparison In Patients Of COVID-19. Pak Armed Forces Med J
; 70(6): 1609–1615.
Xie J, Covassin N, Fan Z, Singh P, Gao W, Li G, et al. Association
Between Hypoxemia and Mortality in Patients With COVID-19.
Mayo Clin Proc 2020; 95(6): 1138–1147.
https://doi.org/10.1016/j.mayocp.2020.04.006
Qi J, He D, Yang D, Wang M, Ma W, Cui H, et al. Severityassociated markers and assessment model for predicting the
severity of COVID-19: a retrospective study in Hangzhou,
China. BMC Infect Dis 2021; 21(1): 1–10.
https://doi.org/10.1186/s12879-021-06509-6
Li J, Chen Z, Nie Y, Ma Y, Guo Q, Dai X. Identification of
Symptoms Prognostic of COVID-19 Severity: Multivariate Data
Analysis of a Case Series in Henan Province. J Med Internet Res
; 22(6). https://doi.org/10.2196/19636
Ameer K, Rafique A, Abbas S, Burki AM, Abbas B. Clinical
Presentation of Mild to Moderate COVID–19 Disease in Patients
Admitted at Tertiary Care Hospital Pakistan. Pak Armed Forces
Med J 2022; 72(1): 284-287.
Liu K, Fang YY, Deng Y, Liu W, Wang MF, Ma JP, et al. Clinical
characteristics of novel coronavirus cases in tertiary hospitals in
Hubei Province. Chin Med J 2020; 133(9): 1025–1031.
https://doi.org/10.1097/CM9.0000000000000744
Chen TL, Dai Z, Mo P, Li X, Ma Z, Song S, et al. Clinical
Characteristics and Outcomes of Older Patients with
Coronavirus Disease 2019 (COVID-19) in Wuhan, China: A
Single-Centered, Retrospective Study. J Gerontol 2020; 75(9):
–1795. https://doi.org/10.1093/gerona/glaa089
Colombi D, Bodini FC, Petrini M, Maffi G, Morelli N, Milanese
G, et al. Well-aerated Lung on Admitting Chest CT to Predict
Adverse Outcome in COVID-19 Pneumonia. Radiology 2020;
(2): E86–96. https://doi.org/10.1148/radiol.2020201433
Inoue A, Takahashi H, Ibe T, Ishii H, Kurata Y, Ishizuka Y, et al.
Comparison of semiquantitative chest CT scoring systems to
estimate severity in coronavirus disease 2019 (COVID-19)
pneumonia. Eur Radiol 2022; 32(5): 3513.
https://doi.org/10.1007/s00330-021-08435-2
Alshanbari HM, Sami W, Mehmood T, Aboud M, Alanazi T,
Hamza MA, et al. Prediction of COVID-19 severity from clinical
and biochemical markers: a single-center study from Saudi
Arabia. Eur Rev Med Pharmacol Sci 2022; 26(7): 2592–2601.
https://doi.org/10.26355/eurrev_202204_28497
Ali N. Elevated level of C‐reactive protein may be an early
marker to predict risk for severity of COVID‐19. J Med Virol
; 92(11): 2409–2411. https://doi.org/10.1002/jmv.26097
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