Coagulopathy Spectrums in COVID-19 Patients at A Tertiary Care Diagnostic Center in Pakistan

Intzar  Ali; Helen Mary  Robert; Komal  Andleeb; Noman Anjum  Rana; Muhammad Bilal  Asghar; Muhammad  Shahid

doi:10.51253/pafmj.v75iSUPPL-2.10113

Authors

Intzar Ali Department of Haematology, Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
Helen Mary Robert Department of Haematology, Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
Komal Andleeb Department of Psychiatry, Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
Noman Anjum Rana Department of Haematology, Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
Muhammad Bilal Asghar Department of Haematology, Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
Muhammad Shahid Department of Medicine, Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75iSUPPL-2.10113

Keywords:

COVID-19, Coagulation, Respiratory Infection

Abstract

Objective: To determine the coagulopathy spectrums in patients with COVID-19 infection at a tertiary care diagnostic center in Pakistan.

Study Design: Cross-sectional study

Place and Duration of Study: Pathology Department, Armed Forces Institute of Pathology, Rawalpindi Pakistan, from Apr to Sep 2021.

Methodology: A total of 196 patients fulfilling the selection criteria were enrolled after taking written informed consent and investigations to assess coagulation parameters were carried out such as complete blood count, PT, APTT and D-Dimers and findings were subjected to statistical analysis.

Results: Mean age of the patients was 35.20±0.98 years. Platelet count was found to be normal in 152(77.6%) patients and low in 44(22.4%) patients, PT was normal in 182(92.9%) patients and prolonged in 14(7.1%) patients, APTT was normal in 152(77.6%) patients and prolonged in 44(22.4%) and D-Dimers was raised in 87(44.4%) patients and was raised in 109(55.6%) patients

Conclusion: The commonest coagulation pathology was D-Dimers i.e. in 52.6% patients, followed by APTT and platelet count in COVID-19 patients of varying severity.

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References

Shukla S, Kamini K, Gupta B, Bahadur S, Kalhan S, Gupta M. Parameters of Coagulation in COVID-19 Patients: A Correlation with Clinical Severity. J Med Microbiol Infect Dis 2022; 10(4): 153-156.

Kashif A, Taj S, Moin S, Fatima SA, Lone A, Ahmed Q. Coagulation profile in COVID-19. Rawal Medical Journal 2022; 47(3): 523-526.

Nazir, I., Hamid, S.M., Shakoor, A., Khan, R.R., Farid, M.A., Imran, I. et al. Pattern of Coagulopathy and Their Association with Mortality in COVID-19 Patients in Makkah, KSA. Pak J Med Health Sci 2022: 16(06): 337-337.

Langer F, Kluge S, Klamroth R, Oldenburg J. Coagulopathy in COVID-19 and its implication for safe and efficacious thromboprophylaxis. Hämostaseol 2020; 40(3): 264-269.

Jandial A, Gupta A, Malviya A, Agastam S, Kumar D. Coagulation abnormalities & thromboprophylaxis in COVID-19. Ind J Med Res 2021; 153(6): 606-610.

Smirnova O, Matvienko O, Korsakova N, Lerner A, Shvedova T, Golovina O, et al. Correlation of coagulation parameters with prognosis of COVID-19. Res Pract Thromb Haemostasis 2021; 5(2): 34-39.

Zhang A, Leng Y, Zhang Y, Wu K, Ji Y, Lei S, et al. Meta-analysis of coagulation parameters associated with disease severity and poor prognosis of COVID-19. Int J Infect Dis 2020; 100: 441-448.

Pal S, Lahiri S, Bhattacharyya K, Ghosh A, Mukhopadhyay T. Coagulopathy biomarkers in mild to moderate CoVID-19 patients admitted in a tertiary care public hospital in eastern India. Al Ameen J Med Sci 2021; 14(3): 190-199.

Xu W, Fei L, Huang CL, Li WX, Xie XD, Li Q, et al. Dynamic changes in coagulation parameters and correlation with disease severity and mortality in patients with COVID-19. Aging 2021; 13(10): 13393-13396.

Srivastava S, Garg I, Dogra V, Bargotya M, Bhattar S, Gupta U,et al. Implications of COVID-19 on Thrombotic Profile of Severely Affected Patients. Pathobiol 2022; 89(6): 407-417.

Jamil SW, Ilyas M, Ahmad N, Bakri S, Hardjianti T, Parewangi ML, et al. Coagulation Profile and Outcomes of COVID-19 Patients at Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Maced J Med Sci 2022; 10(2): 1097-1101.

Santasmita P, Subhayan L, Kuntal B, Amrita G, Tapan M. Coagulopathy biomarkers in mild to moderate COVID-19 patients admitted in a tertiary care public hospital in eastern India. Al Ameen J Med Sci 2021; 14(3): 184-192.

Abd El-Lateef AE, Alghamdi S, Ebid G, Khalil K, Kabrah S, Abdel Ghafar MT. Coagulation profile in COVID-19 patients and its relation to disease severity and overall survival: a single-center study. Bri J Biomed Sci 2022; 79: 10098.

Jin X, Duan Y, Bao T, Gu J, Chen Y, Li Y, et al. The values of coagulation function in COVID-19 patients. PLoS One 2020; 15(10): e0241329.

Lu H, Chen M, Tang S, Yu W. Association of coagulation disturbances with severity of COVID-19: a longitudinal study. Hematol 2021; 26(1): 656-662.

Sayyadi M, Khosravi M, Ghaznavi-Rad E. Contribution value of coagulation abnormalities in COVID-19 prognosis: a bright perspective on the laboratory pattern of patients with coronavirus disease 2019. Eur Rev Med Pharmacol Sci 2021; 25(1): 518-522.

AkhoundiMeybodi Z, Dehghan M, Mousavi SA, Vakili M, Foroghi Nasab N, Shahcheraghi SH, et al. Prevalence and impact of coagulation dysfunction in patients with COVID-19 in Yazd. Health Biotech Biopharm 2022; 6(1): 53-61.

Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. New Engl J Med 2020; 382(18): 1708-1720.

Levi M, Thachil J, Iba T. and Levy J.H. 2020. Coagulation abnormalities and thrombosis in patients with COVID-19. Lancet Haematol 7(6): 438-440.

Sayad B, Rahimi Z. Blood coagulation parameters in patients with severe COVID-19 from Kermanshah Province, Islamic Republic of Iran. East Mediterr Health J 2020; 26(9): 999-1004