Serum Lactate Dehydrogenase as an Indicator of Maternal and Neonatal Outcomes in Hypertensive Disorders of Pregnancy
DOI:
https://doi.org/10.51253/pafmj.v74i2.10077Keywords:
Eclampsia, HELLP syndrome, Lactate dehydrogenase, Pre-eclampsia, Preterm birthAbstract
Objective: To ascertain the sensitivity and specificity of serum lactate dehydrogenase as an indicator for maternal and
neonatal outcomes in hypertensive disorders of pregnancy.
Study Design: Cross-sectional, analytical study.
Place and Duration of Study: Departments of Anesthesia and Gynecology & Obstetrics, Combined Military Hospital, Okara
Cantt Pakistan, from Apr to Sep 2018.
Methodology: Eighty-six pregnant women with pregnancy-induced hypertension were included in our study. Group-A
included pregnant women with raised serum LDH, and Group-B included pregnant women with normal LDH levels. The
patients were followed up until delivery and hospital discharge. Maternal and neonatal outcomes were studied.
Results: The progression to hemolysis elevated liver enzyme low platelet (HELLP) syndrome was 4(4.8%) in Group-A versus
zero in Group-B, p=0.022. The two groups did not vary in mode of delivery (cesarean section in 28 vs. 33); preterm delivery (22
versus 15); intrauterine growth retardation (8 vs. 6); intrauterine demise (9 vs 5); low APGAR at birth (13 vs. 7); eclampsia (3
vs. 3) which were comparable between the two groups, p-value>0.05. For overall maternal outcomes, the sensitivity for raised
LDH was 57.1% and specificity 53.3%. The sensitivity was 51.2%, and the specificity was 54.7% for overall neonatal outcomes.
Conclusion: Elevated serum LDH alone in pregnancy-induced hypertension cannot considered as a prognostic indicator for
maternal and neonatal adverse outcomes, except HELLP syndrome
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