Serum Lactate Dehydrogenase as an Indicator of Maternal and Neonatal Outcomes in Hypertensive Disorders of Pregnancy


  • Sadia Zainab Department of Gyne & obs, Combined Military Hospital Bahawalpur/National University of Medical Sciences (NUMS) Pakistan
  • Amina Akbar Department of Gyne & obs, Pakistan Air Force Hospital, Islamabad/National University of Medical Sciences (NUMS) Pakistan
  • Ambreen Ehsan Department of Gyne & obs, Combined Military Hospital Jhelum/ National University of Medical Sciences (NUMS) Pakistan
  • Sidra Mushtaq Department of Gyne & obs, Bahawal Victoria Hospital, Bhawalpur Pakistan
  • Humaira Tabbasum Department of Gyne & obs, Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Mobeen Ikram Department of Anesthesia, Combined Military Hospital Kharian/National University of Medical Sciences (NUMS) Pakistan



Eclampsia, HELLP syndrome, Lactate dehydrogenase, Pre-eclampsia, Preterm birth


Objective: To ascertain the sensitivity and specificity of serum lactate dehydrogenase as an indicator for maternal and
neonatal outcomes in hypertensive disorders of pregnancy.

Study Design: Cross-sectional, analytical study.

Place and Duration of Study: Departments of Anesthesia and Gynecology & Obstetrics, Combined Military Hospital, Okara
Cantt Pakistan, from Apr to Sep 2018.

Methodology: Eighty-six pregnant women with pregnancy-induced hypertension were included in our study. Group-A
included pregnant women with raised serum LDH, and Group-B included pregnant women with normal LDH levels. The
patients were followed up until delivery and hospital discharge. Maternal and neonatal outcomes were studied.

Results: The progression to hemolysis elevated liver enzyme low platelet (HELLP) syndrome was 4(4.8%) in Group-A versus
zero in Group-B, p=0.022. The two groups did not vary in mode of delivery (cesarean section in 28 vs. 33); preterm delivery (22
versus 15); intrauterine growth retardation (8 vs. 6); intrauterine demise (9 vs 5); low APGAR at birth (13 vs. 7); eclampsia (3
vs. 3) which were comparable between the two groups, p-value>0.05. For overall maternal outcomes, the sensitivity for raised
LDH was 57.1% and specificity 53.3%. The sensitivity was 51.2%, and the specificity was 54.7% for overall neonatal outcomes.

Conclusion: Elevated serum LDH alone in pregnancy-induced hypertension cannot considered as a prognostic indicator for
maternal and neonatal adverse outcomes, except HELLP syndrome


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How to Cite

Zainab S, Akbar A, Ehsan A, Mushtaq S, Tabbasum H, Ikram M. Serum Lactate Dehydrogenase as an Indicator of Maternal and Neonatal Outcomes in Hypertensive Disorders of Pregnancy. Pak Armed Forces Med J [Internet]. 2024 Apr. 29 [cited 2024 May 24];74(2):451-4. Available from:



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