Comparison of Efficacy of Topical Cprofloxacin Ear Drops 0.6% Versus Oral Cprofloxacin 500 mg Twice Daily in Achieving Dry Ear in Chronic Suppurative Otitis Medi

Muhammad Imran Malik; Aiman Fatima Naqvi; Zaimal Shahan; Amir Akbar; Amna Enam; Mohsin Raza

doi:10.51253/pafmj.v74i4.10016

Authors

Muhammad Imran Malik Department of ENT, Fazaia Medical College Pakistan Airforce Hospital Islamabad Pakistan
Aiman Fatima Naqvi Department of ENT, Combined Military Hospital Malir/ National University of Medical Sciences (NUMS) Pakistan
Zaimal Shahan Department of ENT, THQ Kallar Syedan Pakistan
Amir Akbar Department of ENT, Rawal Institute of Health Sciences Islamabd Pakistan
Amna Enam Department of ENT, Sindh Institute of Urology & Transplantation Karachi Pakistan
Mohsin Raza Department of ENT, Combined Military Hospital Abbottabad/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i4.10016

Keywords:

Anti-bacterial agents, Cprofloxacin, Suppurative otitis media, Suppuration.

Abstract

Objective: To compare the efficacy of Cprofloxacin 0.6% ear drops versus oral Cprofloxacin in achieving the dry ears in chronic suppurative otitis media patients presenting at a tertiary care hospital, Islamabad Pakistan.

Study Design: Quasi-experimental study.

Place and Duration of Study: Department of Otorhinolaryngology and Head and Neck Surgery, Pakistan Institute of Medical Sciences, Islamabad Pakistan, from Jun 2022 to Dec 2022.

Methodology: The study recruited 130 patients with unilateral or bilateral chronic ear discharge, of either gender, aged 12-60 years, and divided them into two groups of 65 each. Group-A received topical Cprofloxacin 0.6% in a dose of four drops three times per day, while Group-B, 65 patients received oral Cprofloxacin 500 mg twice daily. Otoscopy was used to monitor patients for two weeks following dry ear treatment.

Results: The mean age of participants was 29.70±9.03 years and most patients were males (60%). Post-treatment results of Group-A revealed that there were 11(16.9%) subjects with ear discharge. The rest 54(83.1%) had no ear discharge. In Group-B, there were 46(70.8%) subjects with ear discharge. The rest 19(29.2%) had no ear discharge. A statistically significant (p=0.001) difference in efficacy was observed between both groups.

Conclusion: Topical Cprofloxacin 0.6% given 6 drops twice daily for two weeks is a better choice in medical management of CSOM than oral Cprofloxacin 500mg twice daily in terms of resolution of ear discharge.

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