Comparison of Hemodynamic Stability of Patients Undergoing Appendectomy under Spinal Anesthesia versus Blend of Ketamine and Midazolam with Spinal Anesthesia

Authors

  • Kaukab Majeed Kayani Department of Anesthesia, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Usman Eijaz MALIK Department of Anesthesia, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Amran Hafiz Department of Anesthesia, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Fayyaz Hussain Department of Anesthesia, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Humayun Munir Department of Anesthesia, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Najm us Saqib Department of Anesthesia, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i4.9481

Keywords:

Anesthesia, Ketamine, Midazolam, Spinal anesthesia

Abstract

Objective: To compare appendectomy under spinal anaesthesia versus combining Ketamine and Midazolam with spinal anaesthesia.

Study Design: Quasi-experimental study.

Place and Duration of Study: Pak Emirates Military Hospital, Rawalpindi, from Jan to June 2022.

Methodology: A sample of 100 patients fulfilling the inclusion/exclusion criteria was collected. A random segregation was made into two equal groups through the lottery method resulting in fifty patients in each Group-50. The Group A patients received spinal anaesthesia while and were given 0.25mg/kg Ketamine and 2mg Midazolam 2 minutes before incision. Group B patients only received spinal anaesthesia. Patients’ hemodynamics were monitored throughout surgery. The primary parameter studied was hemodynamic stability, and the secondary parameter was conversion into general anaesthesia.

Results: The primary outcome was hemodynamic stability. 48(96%) patients remained hemodynamically stable in Group A. Only 2(4%) patients showed hemodynamic instability. The Group B patient had lower hemodynamic stability as 29(58%) patients were hemodynamically unstable versus 21(42%) being stable (p-value <0.001).

Conclusion: Using Ketamine and Midazolam as adjuvants to spinal anaesthesia improves hemodynamic stability and success for open appendectomy.
Keywords: Anesthesia, Ketamine, Midazolam, Spinal anesthesia.

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Published

31-08-2023

How to Cite

1.
Kayani KM, MALIK UE, Hafiz A, Hussain F, Munir H, Saqib N us. Comparison of Hemodynamic Stability of Patients Undergoing Appendectomy under Spinal Anesthesia versus Blend of Ketamine and Midazolam with Spinal Anesthesia. Pak Armed Forces Med J [Internet]. 2023 Aug. 31 [cited 2024 May 26];73(4):1128-32. Available from: https://pafmj.org/PAFMJ/article/view/9481

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