Vestibular Rehabilitation with Intratympanic Drug Therapy in Meniere's Disease

  • Zeeshan Ayub Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Ahmed Hasan Ashfaq Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Amir Ali Khan Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Kamran Ashfaq Ahmed Butt Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Keywords: Dexamethasone, Gentamicin, Intratympanic

Abstract

Objective: To evaluate vertigo control and auditory rescue in patients with Meniere's disease treated with intratympanic Gentamicin and Dexamethasone.

Study Design: Randomized Control Trial (Clinical Trials. gov Identifier: NCT05355610).
Place and Duration of Study: ENT Departments CMH Quetta and Benazir Bhutto Hospital Rawalpindi Pakistan from Apr 2020 to Mar 2022.

Methodology: Ninety-three cases of unilateral Meniere's disease meeting the inclusion criteria were treated with intratym-panic Gentamicin and Dexamethasone. Pre and post-treatment vertigo was assessed on Vestibular Deficit Index. Speech discrimination scores for auditory impact were also recorded pre and post-treatment.

Results: In the Ninety-three treated cases, there was a statistically significant improvement in the Vestibular Deficit Index (with a p-value of 0.001). Although all patients had a reduced speech discrimination score, it was not statistically significant (p value=0.08).

Conclusion: Control of vestibular symptoms can be achieved with intratympanic Gentamicin, and at the same time, the auditory system can be rescued with Dexamethasone.

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Published
2022-10-06
How to Cite
Ayub, Z., Ashfaq, A., Khan, A., & Butt, K. A. (2022). Vestibular Rehabilitation with Intratympanic Drug Therapy in Meniere’s Disease. Pakistan Armed Forces Medical Journal, 72(4), 1444-47. https://doi.org/10.51253/pafmj.v72i4.8696
Section
Original Articles