Evaluation of Reference Interval of Serum Uric Acid Level During Pregnancy in Tertiary Care Hospital of Rawalpindi

Authors

  • Qurat Ul Ain Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Mehwish Gilani Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Naveed Asif Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Ammad Akram Pak Emirate Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Khurshid Muhammad Uttra Pak Emirate Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Amer Siddiq Imam Buri Medical College Islamabad, Pakistan

Keywords:

Pregnancy, Reference interval, Uric acid

Abstract

Objective: To determine the reference interval of uric acid in uncomplicated pregnancies.

Study Design: Cross-sectional study.

Place and Duration of Study: Pathology Department, Armed Forces Institute of Pathology, Rawalpindi Pakistan.

Methodology: Data was collected from 807 pregnant females after informed consent. Healthy females of first and secondtrimester gestational amenorrhea with no previous significant surgical, medical and gynecological/obstetric history were included. In contrast, patients on drugs like anti-epileptics, anti-hypertensives, steroids, and poor obstetric history were excluded. Information regarding dietary, medical and family history and the use of tobacco, beverages, and current physical activity was collected using a standard questionnaire. Reference Interval was computed by using the 3rd and 97th percentile systems.

Results: Mean age of study participants in the first trimester of pregnancy was 22.37 ± 2.54 years, while in the second trimester was 27.14 ± 3.62 years. Data was segregated into three age groups: 18-29 years (186, 23%), 30-35 years (452, 56%) and 36-43 years (169, 21%). Uric acid levels observed in the first and second trimesters were 95.8-260.14 umol/l and 96-268 umol/ respectively.

Conclusion: Serum Uric Acid levels differed in normal pregnancy compared to the non-pregnant state. Moreover, this study also provides optimal reference intervals of uric acid levels for pregnancy's first and second trimesters.

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Published

30-04-2022

Issue

Section

Original Articles

How to Cite

1.
Ain QU, Gilani M, Asif N, Akram A, Uttra KM, Siddiq A. Evaluation of Reference Interval of Serum Uric Acid Level During Pregnancy in Tertiary Care Hospital of Rawalpindi. Pak Armed Forces Med J [Internet]. 2022 Apr. 30 [cited 2024 Jul. 25];72(2):471-74. Available from: https://pafmj.org/PAFMJ/article/view/8648