Prolotherapy Improves Anatomical and Clinical Outcomes in Monosodium Iodoacetate Induced Model of Osteoarthritis

  • Aqsa Zahid Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Khadija Qamar Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Abdullah Qamar Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Tayyaba Faisal Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Zubia Iftikhar Azad Jammu Kashmir Medical College, Muzaffarabad Pakistan
  • Saba Saleem Sialkot Medical College, Sialkot Pakistan
Keywords: Gait cycle, Monosodium iodoacetate, Osteoarthritis, Prolotherapy

Abstract

Objective: To assess the ameliorative effects of Prolotherapy on the pain score of the gait cycle in Monosodium Iodoacetate (MIA) induced osteoarthritis in the rat knee joint.

Study Design: Laboratory-based experimental study.

Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi in collaboration with the National Institute of Health (NIH), Islamabad and Pathology Lab Pak Emirates Rawalpindi, Pakistan, from Aug to Nov 2021.

Methodology: Thirty male Sprague Dawley rats were randomly divided into three groups (n=10 in each group). The control group was Group-A. To induce osteoarthritic changes in Group-B, a single dose of 1mg Monosodium Iodoacetate was injected intra-articularly into the right knee. Group-C received a single dose of 1mg Monosodium Iodoacetate injection in the right knee intra articularly to induce osteoarthritic changes, and was followed by 0.1ml Prolotherapy (3ml of 25% dextrose, 2ml of 2% Xylocaine, 1ml of injection thiamine, and 1ml of injection Methylcobalamin) at 2, 6 and 10 weeks intra articularly into the right knee joint.  Before euthanasia, Pain scoring schemes for gait in rats of all groups were done at 0, 2 and 14 weeks.

Results: The present study concluded that prolotherapy improved the gait cycle pain score in experimental group C (p-value 0.001 on the intergroup comparison at two weeks and 14 weeks while p-value 0.001 when compared pain score within the Group C at 0, 2 and 14 weeks).

Conclusion: Prolotherapy had ameliorative effects on the pain score of the gait cycle in experimental Group C on Monosodium Iodoacetate......

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Published
2022-06-26
How to Cite
Zahid, A., Qamar, K., Qamar, A., Faisal, T., Iftikhar, Z., & Saleem, S. (2022). Prolotherapy Improves Anatomical and Clinical Outcomes in Monosodium Iodoacetate Induced Model of Osteoarthritis. Pakistan Armed Forces Medical Journal (PAFMJ), 72(3), 904-07. https://doi.org/10.51253/pafmj.v72i3.8631
Section
Original Articles

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