Significance of Immature Platelet Fraction in Diagnosed Patients of the Immune Thrombocytopenic Purpura

  • Mohammad Shabih Haider Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Asad Mahmood Armed Forces Institute of Transfusion/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Manzar Bozdar Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Saima Zahir Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Saadia Muzafar Watim Medical College, Rawalpindi Pakistan
  • Maliha Batool Bukhari Polyclinic Hospital Islamabad, Pakistan
Keywords: Immature platelet fraction, Immune thrombocytopenic purpura, Peripheral destruction of platelets

Abstract

Objective: Determination of significance of immature platelet fraction (IPF%) in diagnosed patients of Immune thrombocytopenic purpura (ITP).

Study Design: It was a cross-sectional study.

Place and Study Duration: Haematology department, Armed forces Institute of Pathology (AFIP), Rawalpindi Pakistan June 2021 to December 2021.

Methodology: Patients of all ages and genders diagnosed with ITP and platelets less than 100 x 109/L after a review of peripheral blood film were included in the study. Detailed history and examination were made, complete blood count (CBC) test was done on Sysmex XN-3000 automated haematology analyzer. Peripheral blood was stained with Leishman stain and examined under a microscope to rule out pseudo thrombocytopenia and the presence of abnormal cells and dysplasia. After adequate quality and control, the immature platelet fraction was performed on Sysmex XN 3000.

Results: Seventy-two diagnosed cases of immune thrombocytopenic purpura were part of the study. The mean age of the patients was 21.00±14.50 years. 34 (48%) patients were males, and 38 (52%) were females. The mean platelet count was 49.40±24.60. Mean IPF was 17.90±9.50 per microliter. Immature platelet fraction (IPF%) was raised in all the patients with immune thrombocytopenic purpura, confirming our hypothesis that IPF% was an independent predictor for the detection of ITP.

Conclusion: Immature platelet fraction is a unique parameter that can pick patients having thrombocytopenia due to peripheral destruction, including immune thrombocytopenic purpura.

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Published
2022-09-07
How to Cite
Haider, M., Mahmood, A., Bozdar, M., Zahir, S., Muzafar, S., & Bukhari, M. (2022). Significance of Immature Platelet Fraction in Diagnosed Patients of the Immune Thrombocytopenic Purpura. Pakistan Armed Forces Medical Journal (PAFMJ), 72(4), 1420-23. https://doi.org/10.51253/pafmj.v72i4.8376
Section
Original Articles

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