Comparison Study of 18F-FDG Production Utilizing FDG Single Citrate and FDG Duo Citrate Cassette on FASTlab2 Synthesizer at AFIRI, Rawalpindi

Authors

  • Mudassar Ahmad Department of Orthopedics, Armed Forces Institute of Radiology and Imaging/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Rizwan Bilal Department of Orthopedics, Armed Forces Institute of Radiology and Imaging/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Atiq Ur Rehman Slehria Department of Orthopedics, Armed Forces Institute of Radiology and Imaging/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Ali Jamal Department of Orthopedics, Armed Forces Institute of Radiology and Imaging/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Syed Ali Mehdi Department of Orthopedics, Armed Forces Institute of Radiology and Imaging/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Nisar Ahmed Armed Forces Institute of Radiology and Imaging (AFIRI) Rawalpindi

DOI:

https://doi.org/10.51253/pafmj.v73i4.8026

Keywords:

EYDC (estimated yield decay corrected), FASTlab2, EYUC (estimated yield uncorrected), pH and Volume of the tracer, RCP (radiochemical purity), Synthesis duration

Abstract

Objective: To compare and observe the differences of 18F-FDG produced using FDG citrate and FDG duo citrate cassette on the GE Healthcare FASTlab2 Synthesizer system following standard operating parameters.

Study Design: Quasi-experimental study.

Place and Duration of Study: Armed Forces Institute of Radiology and Imaging, Rawalpindi Pakistan, from Sep 2020 to Aug 2021.

Methodology: Comparison of 18F-FDG produced using FDG citrate and FDG duo citrate cassette on FASTlab2 consists of evaluating the estimated yield uncorrected (EYUC), estimated yield decay corrected (EYDC), radiochemical purity (RCP), synthesis duration and tracer volume in both cassettes. Sixty Batches of each FDG citrate and duo citrate cassettes were utilized to obtain the required results.

Results: Results acquired by comparing the mean yield of FDG citrate and FDG duo citrate cassette were 74.98±8.92% for EYUC and 86.35±10.26% for EYDC for the FDG citrate cassette. At the same time, the mean RCP turned out to be 99.58±1.06% for the citrate cassette and 99.9±0.35 for the duo citrate cassette. The mean synthesis duration of FDG was 24.21±0.76min and 24.75±0.43min for the citrate cassette and duo citrate cassette correspondingly, and the volume of the tracer was 3.5ml for both cassettes.

Conclusion: The results obtained by comparing these two cassettes were within the range of acceptable limits as claimed by the manufacturer, with a single cassette offering more yield as compared to a duo cassette, while the radiochemical purity, pH
and volume of the tracer were found to be identical in both cassettes.

Downloads

Download data is not yet available.

Author Biography

  • Ali Jamal, Department of Orthopedics, Armed Forces Institute of Radiology and Imaging/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

    Nuclear Medicine Consultant 

Downloads

Published

30-08-2023

Issue

Section

Original Articles

How to Cite

1.
Ahmad M, Bilal R, Slehria AUR, Jamal A, Mehdi SA, Ahmed N. Comparison Study of 18F-FDG Production Utilizing FDG Single Citrate and FDG Duo Citrate Cassette on FASTlab2 Synthesizer at AFIRI, Rawalpindi. Pak Armed Forces Med J [Internet]. 2023 Aug. 30 [cited 2024 Jul. 14];73(4):977-81. Available from: https://pafmj.org/PAFMJ/article/view/8026