Burkholderia Cepacia: An Emerging Superbug in Intensive Care Unit Settings of Tertiary Care Hospitals in Pakistan

Rafia Irfan; Amna Amer; Irfan Ali Mirza; Wajid Hussain; Mariam Sarwar; Mahtab Akhtar

doi:10.51253/pafmj.v72i5.7635

Authors

Rafia Irfan Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Amna Amer Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Irfan Ali Mirza Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Wajid Hussain Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Mariam Sarwar Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Mahtab Akhtar Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v72i5.7635

Keywords:

Antimicrobial susceptibility, Bloodstream infections, Burkholderia cepacia complex (BCC), Minocycline, Multidrug resistance

Abstract

Objective: To determine the frequency, risk factors, and antibiotic susceptibility pattern of Burkholderia cepacia isolates from clinical specimens in a Pakistani tertiary care hospital.

Study Design: Cross-sectional Study

Place and Duration of Study: Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi Pakistan, from Jul 2017 to Jun 2021.

Methodology: The Burkholderia cepacia strains were isolated from clinical samples by routine microbiological methods. In our laboratory, the identification and antimicrobial susceptibility testing of the isolate were made by API 20NE and VITEK-2 Automated Microbiology Analyzer.

Results: Four hundred and nineteen (419) str5-ains of Burkholderia cepacia were isolated during the study period. Among them,277(66.1%) and 57(13.6%) isolates were from blood cultures and lower respiratory tracts, respectively. The antibiotic-resistant rates of the isolates of Minocycline, Cotrimoxazole, Levofloxacin, Meropenem, and Ceftazidime were 13(3.1%), 26(6.2%), 49(11.6%),74(17.6%) and 118(28.16%) respectively.

Conclusion: We observed a gradual increase in the frequency of isolation. A surge in antimicrobial resistance was also seen during the study period underscoring the need for rigorous implementation of antimicrobial stewardship programs and infection control practices.