Diagnostic Accuracy of PET/CT in Detecting Aggressiveness of Lymphoma Based on Sub Uptake

  • Sana waqar Armed Forces Institute of Radiology & Imaging/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Tariq Saeed Siddiqui Armed Forces Institute of Radiology & Imaging/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Hafsa Sadiq Armed Forces Institute of Radiology & Imaging/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Haroon Sarfraz Pof Hospital Wah Cantt, Pakistan
  • Kiran Sarfraz Lahore General Hospital, Lahore, Pakistan
  • Muhammad Mannan Armed Forces Institute of Radiology & Imaging/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: Bone marrow biopsy, 18-FDG PET/CT SUV, Lymphomas

Abstract

Objective: To determine the diagnostic accuracy of PET/CT in detecting aggressiveness of lymphoma based on sub-uptake keeping bone marrow biopsy as the gold standard.

Study Design: Prospective longitudinal study.

Place and Duration of Study: Armed Forces Institute of Radiology and Imaging, Rawalpindi Pakistan, from Sep 2020 to Mar 2021.

Methodology: One hundred thirty-eight patients of either gender, aged 20 to 80 years who were diagnosed with lymphoma (either Hodgkin’s or non-Hodgkin’s lymphoma) on initial PET/CT scan were enrolled in the study. All patients underwent PET/CT, and 18-FDG SUV was calculated. After obtaining values, all participants underwent bone marrow biopsy to determine the aggressiveness of lymphoma and findings were subjected to statistical analysis.

Results: The mean age of the patients was 54.92±16.86, and the mean SUV value was 17.04±8.03. There were 77(55.8%) males and 61(44.2%) females. Hodgkin’s lymphoma was present in 28 (20.3%) patients and non-Hodgkin’s lymphoma in 110(79.7%). The sensitivity, specificity, PPV, NPV and diagnostic accuracy of 18 FDG PET/CT SUV were 92%, 92.2%, 93.2%, 90.9% and 92.1%, respectively.

Conclusion: 18-FDG PET/CT SUV has high diagnostic accuracy and can detect aggressive lymphomas and further specify the areas for biopsy.

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Published
2023-04-20
How to Cite
waqar, S., Siddiqui, T., Sadiq, H., Sarfraz, M. H., Sarfraz, K., & Mannan, M. (2023). Diagnostic Accuracy of PET/CT in Detecting Aggressiveness of Lymphoma Based on Sub Uptake. Pakistan Armed Forces Medical Journal, 73(2), 494-97. https://doi.org/10.51253/pafmj.v73i2.7593
Section
Original Articles