Efficacy and Toxicity of Hypofractionated Palliative Radiotherapy for Breast Cancer Patients with Skin Invasion

Authors

  • Talha Maqsood Department of Oncology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Adnan Zeb Department of Oncology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Zeeshan Ahmed Alvi Department of Oncology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Sameed Hussain Department of Oncology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Imran Wajid Department of Oncology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Omer Riaz Department of Oncology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i4.7443

Keywords:

Breast cancer, Hypofractionated hypofractionated palliative radiotherapy, Palliative therapy

Abstract

Objectives: To determine the efficacy and toxicity of palliative radiotherapy for locally advanced breast cancer patients with skin invasion.

Study Design: Quasi-experimental study.

Place and Duration of Study: Radiotherapy Department Combined Military Hospital, Rawalpindi Pakistan, Jan 2019 to Jun 2020.

Methodology: Patients who received palliative radiotherapy for the breast cancer and received radiation of 24 Gray in 3 fractions to the breast/ chest wall were included. Radiation toxicity was assessed using RTOG criteria as the primary outcome of the study. Radiotherapy efficacy in controlling bleeding/discharge and improving pain and odour scores were the secondary outcomes.

Results: Twelve (80%) patients reported improvement in pain, 13/18(72.2) patients reported improvement in bleeding and 24/25 (96%) patients a decrease in pain level (p-value < 0.001). 11/25(44%) developed Grade-2 skin toxicity, and 8/25 (32%) developed Grade-3 skin toxicity. No patient experienced Grade-4 skin toxicity.

Conclusion: Our study has shown that hypofractionated radiotherapy is effective and safe for palliation of patients with locally advanced breast cancer and skin invasion.

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Published

31-08-2023

Issue

Section

Original Articles

How to Cite

1.
Maqsood T, Zeb A, Alvi ZA, Hussain S, Wajid MI, Riaz O. Efficacy and Toxicity of Hypofractionated Palliative Radiotherapy for Breast Cancer Patients with Skin Invasion. Pak Armed Forces Med J [Internet]. 2023 Aug. 31 [cited 2024 Jul. 19];73(4):1060-2. Available from: https://pafmj.org/PAFMJ/article/view/7443