Efficacy of Topical 0.05% Isotretinoin Gel Versus 0.1% Adapalene Gel in The Treatment of Mild to Moderate Acne Vulgaris

Summaya Saleem; Naeem Raza; Nida Saleem; Saleem Ullah; Ghazala Yasmin; Farrah Yousaf

doi:10.51253/pafmj.v73i1.6472

Authors

Summaya Saleem Pak Emirates Military Hospital/National University of Medical Science(NUMS) Rawalpindi Pakistan
Naeem Raza Pak Emirates Military Hospital/National University of Medical Science(NUMS) Rawalpindi Pakistan
Nida Saleem Armed Forces Institute of Mental Health/National University of Medical Science(NUMS) Rawalpindi Pakistan
Saleem Ullah Quetta Institute of Medical Science, Quetta Pakistan
Ghazala Yasmin Pak Emirates Military Hospital/National University of Medical Science(NUMS) Rawalpindi Pakistan
Farrah Yousaf Pak Emirates Military Hospital/National University of Medical Science(NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i1.6472

Keywords:

Acne vulgaris, Adapalene gel, Isotretinoin gel, Efficacy

Abstract

Objective: To compare the efficacy of topical 0.05% Isotretinoin gel versus 0.1% Adapalene gel in treating mild to moderate acne vulgaris.

Study Design: Quasi-Experimental study.

Place and Duration of Study: Department of Dermatology, Pak Emirates Military Hospital (PEMH), Rawalpindi Pakistan, From Feb to Jul 2018.

Methodology: A total of ninety-two patients aged 12 to 25 years with mild to moderate facial acne vulgaris were enrolled and divided into two treatment Groups, Group-A (0.05% Isotretinoin Gel) and Group-B (0.1% Adapalene Gel). Efficacy was measured at 12 weeks post-treatment.

Results: Treatment was found efficacious in 84.8% (n=39/46) of patients in Group-A and 50.0% (n=23/46) of patients in Group-B (p= 0.001). There were similar results when treatment efficacy in both Groups was disease severity. In all cases,efficacy was better in Group-A (p<0.05).

Conclusions: The efficacy of topical 0.05% Isotretinoin gel was better than topical 0.1% Adapalene gel for treating mild to moderate acne vulgaris.