EXPERIENCE WITH DOLUTEGRAVIR IN HIV PATIENTS AT A PUBLIC SECTOR HOSPITAL IN KARACHI, PAKISTAN

Dolutegravir in HIV

  • Farzana Batool Shaheed Mohtarma Benazir Bhutto Institute of Trauma & Civil Hospital, Karachi Pakistan
  • Sohaima Manzoor Shaheed Mohtarma Benazir Bhutto Institute of Trauma & Civil Hospital, Karachi Pakistan
  • Azizullah Khan Dhiloo Dow University of Health Sciences, Karachi Pakistan
  • Humera Muhammad Ismail Shaheed Mohtarma Benazir Bhutto Institute of Trauma & Civil Hospital, Karachi Pakistan
  • Shah Muhammad Shaikh Civil Hospital, Karachi Pakistan
  • Shehla Baqi Shaheed Mohtarma Benazir Bhutto Institute of Trauma & Civil Hospital, Karachi Pakistan
Keywords: Antiretroviral therapy, Dolutegravir, Efficacy, HIV, Integrase Inhibitor, Outcome, Pakistan, Tolerability

Abstract

Objective: To study the tolerability and efficacy of dolutegravir in naïve and experienced patients, their management and outcome.

Study Design: Cross sectional study.

Place and Duration of Study: Ruth KM Pfau Civil Hospital, Karachi Pakistan, from Apr 2018 to Apr 2020.

Methodology: In this study all treatment-naïve and experienced HIV infected patients were included and started on integrase strand-transfer inhibitor dolutegravir (DTG) containing fixed dose combination at Sindh AIDS Control Program (SACP) was conducted. We documented virological suppression, defined as a viral load of <1000 copies/ml, immunological and clinical outcomes.

Results: Eighty-two patients, of whom 53 (64.6%) were ARV naïve and 29 (35.4%) experienced, were started on DTG. Fifty six (68.3%) were males. The median age was 31.6 ± 9. Of 82, 61 returned for their first follow-up visit for assessment and viral load determination. Of 61, adverse effects to DTG were reported in 12 (19.6%), including 9 with pruritis. Of 35 naive patients, 30 achieved virological suppression by 3.3 ± 0.7 months and 1 at 8 months. All 26 experienced patients achieved virological suppression by 4.5 ± 0.9 months. Overall, of 61 patients, 57 (93.4%) achieved virological suppression, of whom 1 had immunelogical failure and none had clinical failure after 6 months of DTG. Three (3.6%) patients died within the first two months of
initiating DTG.

Conclusion: Dolutegravir has good tolerability, with virological suppression achieved in the majority, including in highly ARV experienced patients.

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Published
2021-10-31
How to Cite
Batool, F., Manzoor, S., Dhiloo, A., Ismail, H., Shaikh, S., & Baqi, S. (2021). EXPERIENCE WITH DOLUTEGRAVIR IN HIV PATIENTS AT A PUBLIC SECTOR HOSPITAL IN KARACHI, PAKISTAN. PAFMJ, 71(5), 1661-65. https://doi.org/10.51253/pafmj.v71i5.6288
Section
Original Articles

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