Comparison among the Atherogenic Index of Plasma, Ratios of Lipoproteins, Apolipoproteins and Cholesterol Retention Factor (CRF) inPatients with Metabolic Syndrome

Sikandar Hayat Khan; Ahmed Hayat Afzal; Mehreen Gilani; Faisal Naveed Akhtar; Rahat Shahid

doi:10.51253/pafmj.v73i3.6280

Authors

Sikandar Hayat Khan Department of Pathology, Pakistan Naval Ship, Hafeez Hospital, Karachi Pakistan
Ahmed Hayat Afzal Medical Student, Liaquat National Medical College, Karachi Pakistan
Mehreen Gilani Department of Pathology, Pakistan Naval Ship, Hafeez Hospital, Karachi Pakistan
Faisal Naveed Akhtar Department of Medicine, Pakistan Naval Ship, Hafeez Hospital, Karachi Pakistan
Rahat Shahid Department of Radiology, Pakistan Naval Ship, Hafeez Hospital, Karachi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i3.6280

Keywords:

Atherogenic index of plasma (AIP), Apo-B/Apo-A1, Cholesterol retention factor (CRF), HDLc/LDLc, HOMA-IR

Abstract

Objective: To evaluate various lipid, lipoprotein and apolipoprotein ratios among participants with and without metabolic syndrome.

Study Design: Comparative cross-sectional study.

Place and Duration of Study: Naval Hospital, Islamabad Pakistan, from Jan 2019 to Dec 2020.

Methodology: We selected 164 patients with metabolic syndrome. Metabolic syndrome was diagnosed as per “NCEP-defined metabolic syndrome criteria”. Insulin resistance was calculated using Homeostasis Model Assessment for Insulin Resistance (HOMA-IR). Various apolipoproteins were calculated using the turbidimetric method on Humastar-200 and lipoproteins by direct detergent methods.

Results: The differences for Apo-B/Apo-A1 were found to be higher among metabolic syndrome subjects [{Metabolic syndrome (n=83):0.55±0.22} vs {Non-Metabolic syndrome (n=81):0.50±0.29}, p=0.271]. Area Under Curve (AUC) was highest for the atherogenic index of plasma [0.744], followed by both total cholesterol/HDLc [0.641], Cholesterol Retention Factor (CRF) having [0.641], Apo-B/Apo-A1[0.593] and HDLc/LDLc [0.418].

Conclusion: Differences between subjects with and without NCEP-defined metabolic syndrome were significant for the atherogenic index of plasma (AIP), HDLc/LDLc, and Cholesterol Retention Factor (CRF).