Diagnostic Accuracy of Ultrasound to Differentiate Neoplastic and Non-Neoplastic causes of Cervical Lymphadenopathy taking Histopathology as the Gold Standard

Authors

  • Aqeel Shafi Department of Radiology, Pakistan Institute of Medical Sciences, Islamabad Pakistan
  • Shahla Zameer Department of Radiology, Pakistan Institute of Medical Sciences, Islamabad Pakistan
  • Muhammad Nauman Malik Department of Radiology, Pakistan Institute of Medical Sciences, Islamabad Pakistan
  • Rabia Liaqat Department of Radiology, Pakistan Institute of Medical Sciences, Islamabad Pakistan
  • Bushra Liaqat Department of Radiology, Rawalpindi Medical University, Rawalpindi Pakistan
  • Asiya Liaqat Department of Radiology, University of Sciences and Technology (NUST), Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i4.6234

Keywords:

Colour doppler, Lymph node, Neoplastic, Non-neoplastic, Ultrasound

Abstract

Objective: To evaluate the efficacy of high-resolution ultrasound and colour Doppler in differentiating neoplastic and nonneoplastic causes of cervical lymphadenopathy compared to histopathological diagnosis.

Study Design: Cross-Sectional study.

Place and Duration of Study: Pakistan Institute of Medical Sciences, Islamabad Pakistan, from Jan to Jun 2019.

Methodology: The study included 110 patients with palpable cervical lymph nodes undergoing neck ultrasound and Fine needle aspiration cytology/Biopsy. Certain important sonological features were considered to categorize them into nonneoplastic and neoplastic groups. Colour Doppler imaging was employed along with grey-scale imaging. The histopathology results were compared with sonographic findings to determine the diagnostic accuracy of ultrasound in differentiating neoplastic from non-neoplastic causes of enlarged cervical lymph nodes.

Results: Our study revealed that High-resolution sonography has 94.4% sensitivity and 88.8% specificity, differentiating between neoplastic and non-neoplastic causes of cervical lymphadenopathy. At the same time, the overall accuracy of ultrasound is 90.9%. The most consistent grey-scale feature in the non-neoplastic nodal group was preserved central fatty hilum, while its loss was significantly associated with neoplastic etiologies.
Conclusion: Due to high sensitivity and negative predictive value, high-resolution sonography can be deployed as a first-line investigating tool for enlarged lymph nodes, and invasive procedures like Fine needle aspiration cytology (FNAC) can be abandoned in non-neoplastic lymphadenopathies.

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Published

30-08-2023

Issue

Section

Original Articles

How to Cite

1.
Shafi A, Zameer S, Malik MN, Liaqat R, Liaqat B, Liaqat A. Diagnostic Accuracy of Ultrasound to Differentiate Neoplastic and Non-Neoplastic causes of Cervical Lymphadenopathy taking Histopathology as the Gold Standard. Pak Armed Forces Med J [Internet]. 2023 Aug. 30 [cited 2024 Jun. 15];73(4):1024-7. Available from: https://pafmj.org/PAFMJ/article/view/6234