COMPARISON OF EFFECTIVENESS OF CARBAMAZEPINE VERSUS TOPIRAMATE FOR THE MANAGEMENT OF TRIGEMINAL NEURALGIA

Authors

  • Ramish Tariq Allied Hospital, Faisalabad Pakistan
  • Omer Sefvan Janjua Allied Hospital, Faisalabad Pakistan
  • Sana Mehmood Allied Hospital, Faisalabad Pakistan
  • Muhammad Usman Khalid Allied Hospital, Faisalabad Pakistan
  • Khurram Jah Zafar Allied Hospital, Faisalabad Pakistan
  • Saad Hameed Allied Hospital, Faisalabad Pakistan

DOI:

https://doi.org/10.51253/pafmj.v71i4.6083

Keywords:

Carbamazepine, Topiramate, Trigeminal Neuralgia

Abstract

Objective: To compare the effectiveness of Carbamazepine versus Topiramate for the management of trigeminal neuralgia.

Study Design: Comparative prospective study.

Place and Duration of Study: Oral and Maxillofacial Surgery department, Allied Hospital, Faisalabad Pakistan, from Nov 2017 to Nov 2018.

Methodology: A total of 60 patients (30 in each group) were included. Group A was treated with Carbamazepine 100mg TDS and group B with Topiramate 25mg TDS. Visual analogue scale was used to access pain and was calculated at 1st visit (baseline), at 7th day, at 14th day and at 28th day.

Results: Out of 60 patients, mean of age was 54.78 ± 8.49 years. Right and left side of the face was involved in 41 (68.3%) and 19 (31.7%) patients respectively. Maxillary branch was involved in 24 (40%) and mandibular branch was involved in 36 (60%) patients. The mean of visual analogue scale after 7 days in group A was 4.53 ± 0.93 and in group B was 7.1 ± 1.07, after 14 days mean of visual analogue scale in group A was 3.7 ± 1.02 and in group B was 4.03 ± 1.27. Mean of visual analogue scale after 28 days in group A was 3.27 ± 1.01 3.93 ± 1.28. The results were statistically significant with p-value of 0.03.

Conclusion: Topiramate has comparable efficacy as that of Carbamazepine at dose of 75-100mg with lesser side effects. So Topiramate can be used as first line of treatment in trigeminal neuralgia.

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Published

27-08-2021

Issue

Section

Original Articles

How to Cite

1.
Tariq R, Janjua OS, Mehmood S, Khalid MU, Zafar KJ, Hameed S. COMPARISON OF EFFECTIVENESS OF CARBAMAZEPINE VERSUS TOPIRAMATE FOR THE MANAGEMENT OF TRIGEMINAL NEURALGIA. Pak Armed Forces Med J [Internet]. 2021 Aug. 27 [cited 2024 Nov. 25];71(4):1360-63. Available from: https://pafmj.org/PAFMJ/article/view/6083