DIAGNOSTIC SIGNIFICANCE OF MEASURING RETICULOCYTE MATURITY INDICES IN IRON DEFICIENCY ANAEMIA

  • Tanweer Ahmed Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Asad Mahmood Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Nasir Uddin Combined Military Hospital Lahore/ National University of Medical Sciences (NUMS) Pakistan
  • Helen Mary Robert Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Rafia Mahmood Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Usman Tahir Swatti Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: High fluorescence ratio, Iron deficiency anaemia, Medium fluorescence ratio, Reticulocyte maturity indices

Abstract

Objective: To evaluate the diagnostic significance of reticulocyte maturity indices in iron deficiency anaemia.

Study Design: Comparative cross-sectional study.

Place and Duration of Study: Department of Hematology, Armed Forces Institute of Pathology, Rawalpindi, from Sep 2019 to Jun 2020.

Methodology: A total of 340 children, ages between 1 and 5 years of either gender, were divided into two groups based on haemoglobin and ferritin level. Group A comprised of 203 children with haemoglobin >11 g/dL andferritin level >7 ng/ mL. Group B comprised of 137 children with haemoglobin <11g/dL and ferritin <7 ng/mL. Red blood cell and reticulocyte parameters were compared.

Results: Iron deficiency anaemia was found to be 37.6% in the study population. Comparison revealed that the children in groups B had significantly higher mean red cell distribution width (17.1 ± 1.3% vs. 13.3 ± 1.3%) and significantly lower hemoglobin (9.5 ± 1.0 g/dL vs. 12.7 ± 1.0 g/dL), mean corpuscular hemoglobin (21.8 ± 2.5 pg vs. 28.6 ± 2.3 pg), mean corpuscular volume (69.4 ± 3.5 fL vs. 80.4 ± 3.3 fL), mean corpuscular hemoglobin concentration (31.5 ± 1.8 g/dL vs. 32.7 ± 1.6 g/dL) and serum ferritin level (4.5 ± 2.6 mg/mL vs. 55.9 ± 32.1 ng/mL). No significant differences in the mean total red blood cell count, hematocrit and reticulocytes between two groups were noted (p>0.05) and significant differences were noted in terms of low, medium & high fluorescence ratios in both groups (p<0.05).

Conclusion: Our findings suggest that medium fluorescence ratio and high fluorescence ratio.......

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Author Biographies

Asad Mahmood, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

Brig Asad Mahmood is a consultant haematologist and HOD haematology department at AFIP.

Nasir Uddin, Combined Military Hospital Lahore/ National University of Medical Sciences (NUMS) Pakistan

Brig nasir-Ud-Din is Consultant haematologist and HOD haematology department at CMH Lahore.

Helen Mary Robert, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

Lt Col Helen Mary Robert is cnsultant Haematologist at CMH Lahore.

Usman Tahir Swatti, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

Maj Usman Tahir Swati is resident hematologist at AFIP Rawalpindi

Published
2021-12-31
How to Cite
Ahmed, T., Mahmood, A., Uddin, N., Robert, H., Mahmood, R., & Swatti, U. (2021). DIAGNOSTIC SIGNIFICANCE OF MEASURING RETICULOCYTE MATURITY INDICES IN IRON DEFICIENCY ANAEMIA. PAFMJ, 71(6), 2109-13. https://doi.org/10.51253/pafmj.v71i6.5642
Section
Original Articles

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