EFFECT OF SINGLE DOSE OF KETAMINE IN PATIENTS OF MAJOR DEPRESSIVE DISORDER-A PAKISTANI PERSPECTIVE

  • Muhammad Siddique Kakar Combined Military Hospital Gilgit/National University of Medical Sciences (NUMS) Pakistan
  • Mansoor Mustafa Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Haroon Khattak Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Syed Khurram Naseer 130 Medical Battalion/National University of Medical Sciences (NUMS) Pakistan
Keywords: Ketamine, Major depressive disorder MDD, NMDA receptor

Abstract

Objective: To evaluate the effect of a single dose of Ketamine in treatment of severe Major Depressive Disorder MDD in Pakistani patients.

Study Design: Quasi-experimental study.

Place and Duration of Study: The study was conducted at Combined Military Hospital, Gilgit, from Apr 2017 to Mar 2018.

Methodology: Twenty nine subjects for this study had a primary diagnosis of severe Major Depressive disorder with a score of more than 19 on the HAM-D (Hamilton rating scale for depression) scale. These patients were divided into two groups. Group A received injection ketamine IV whereas group B received placebo 0.9% normal saline. Both were reassessed after 24 hours and there HAM-D scores were measured again.

Results: Out of the total 29 patients, response was present in 14 (48.2%) and 15 (51.8%) did not respond to the treatment. Out of 19 patients that were treated with ketamine, 12 (63.1%) showed response to treatment while 7 (36.9%) did not respond. Out of 10 patients that were treated with placebo, 2 (20%) showed response to treatment while 8 (80%) did not respond. The p-value with a confidence interval of 95% was 0.033 showing that the difference in the two treatments was statistically significant.

Conclusion: Ketamine demonstrated rapid antidepressant effects in this study, further supporting N-methyl-Daspartate (NMDA) receptor modulation as a novel mechanism for accelerated improvement in severe forms of depression. However further trials are needed to establish long term effects of the drug.

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Published
2020-10-30
How to Cite
Kakar, M., Mustafa, M., Khattak, H., & Naseer, S. (2020). EFFECT OF SINGLE DOSE OF KETAMINE IN PATIENTS OF MAJOR DEPRESSIVE DISORDER-A PAKISTANI PERSPECTIVE. Pakistan Armed Forces Medical Journal, 70(5), 1332-36. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/5559
Section
Original Articles