COMPARATIVE ANALYSIS OF COLON PREPARATION USING POLY ETHYLENE GLYCOL (PEG) WITH LACTULOSE FOR COLONOSCOPY

  • Asma Asghar Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Laima Alam Bahria Town International Hospital, Rawalpindi Pakistan
  • Asif Farooq Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Arshad Hayat Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Farrukh Saeed Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Jehangir Ahmed Perveen Akhtar Hospital, Kotli Pakistan
Keywords: Bowel preparation, Colonoscopy, Lactulose, Ottawa score, Polyethylene glycol (PEG)

Abstract

Objective: To compare the adequacy of preparation for colonoscopy using polyethylene glycol with lactulose.

Study Design: Quasi experimental study.

Place and Duration of Study: Department of Gastroenterology, Combined Military Hospital Lahore, from Jul 2019 to Dec 2019.

Methodology: The enrolled patients were randomized into two equal groups. Group A received polyethylene glycol (PEG) formulation containing 13.125g x 24 sachets with 4 liters of water over 24 hours, group B received lactulose 600ml (66.7g/100ml) with 4 liters of water over 24 hours. Quality of bowel preparation was assessed using Ottawa scoring system (OBPS). A designed questionnaire was used for recording patients’ tolerability toward the preparation method. Questionnaire was filled pre and post-procedure for socio-demographic data and scores. Patients were also assessed for tolerability of procedure and palatability of the solutions by questionnaire.

Results: The median age of patients in group A was 49 (26 IQR) years and in group B was 48 (18.5 IQR) years. Out of 100 patients 60% were males and 40% were females. The most common indication of colonoscopy was anemia (32%), followed by diarrhea (26%), bleeding per-rectum (24%) and constipation (18%). Polyethylene glycol showed better bowel cleansing score compared with lactulose (p<0.001). Tolerability and palatability for polyethylene glycol were statistically superior to the same volume of lactulose.

Conclusion: Polyethylene glycol is superior to lactulose in terms of bowel preparation, tolerability and palatability.

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Published
2020-10-30
How to Cite
Asghar, A., Alam, L., Farooq, A., Hayat, A., Saeed, F., & Ahmed, J. (2020). COMPARATIVE ANALYSIS OF COLON PREPARATION USING POLY ETHYLENE GLYCOL (PEG) WITH LACTULOSE FOR COLONOSCOPY. Pakistan Armed Forces Medical Journal, 70(5), 1261-65. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/5546
Section
Original Articles

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