COMPARISON OF LIPID PROFILE IN PATIENTS WITH DIABETIC NEUROPATHY AND WITHOUT NEUROPATHY; A CROSS SECTIONAL STUDY

Abstract

Objective: To compare lipid profile in patients with diabetic neuropathy and without neuropathy.

Study Design: Cross-sectional comparative study.

Place and Duration of Study: This study was carried out at Multidisciplinary Lab-1, Department of Biochemistry and Molecular Biology, Army Medical College, from Jan 2020 to Sep 2020 in collaboration with Pak-Emirates Military Hospital, Rawalpindi.

Methodology: Eighty-four subjects were selected and divided into three groups, twenty-eight in each. Group I
included diagnosed patients with type 2 diabetes mellitus with peripheral neuropathy, group II included diagnosed patients with type 2 diabetes mellitus without peripheral neuropathy and group III consisted of healthy individuals. Biochemical parameters including total cholesterol, triglycerides, high density lipoprotein cholesterol and low density lipoprotein cholesterol were measured. Data was analyzed by SPSS version 22.0. One way ANOVA test was used that followed by post-Hoc Tukey test for group comparison.

Results: There was significant difference in triglycerides (p-value 0.001) and high density lipoprotein cholesterol
(0.003) levels among group I and III. While, between group II and III significant difference of high density lipoprotein cholesterol was present. There was no significant difference between group I and II regarding all lipid profile parameters.

Conclusion: There was significant increase of triglycerides levels and decrease of high density lipoprotein
cholesterol in patients with diabetic peripheral neuropathy as compared to healthy controls. No significant
difference was observed for all parameters of lipid profile between patients with diabetic peripheral neuropathy
and without peripheral neuropathy.