HISTOPATHOLOGICAL CHANGES IN PLACENTAL TISSUE OF COVID–19 PREGNANT WOMEN DELIVERED AT PAK EMIRATE MILITARY HOSPITAL, RAWALPINDI

  • Samina Waqar Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Aiza Saadia Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Zainab Abbas Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Farhan Akhtar Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Abeera Choudry Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Jehan Ara Rafiq Baig Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: COVID-19, Placenta, Thrombosis

Abstract

Objective: To document the histological changes in the placentas of COVID-19 pregnant women.

Study Design: Case series.

Place and Duration of Study: Gynaecology department of Pak Emirate Military Hospital, from Mar 2020 to Jul 2020.

Methodology: Nine placentas of COVID-19 positive women were included in the study. Placentas of patients with other co-morbid conditions (diabetes, hypertension, pre eclampsia, eclampsia or any infection) were excluded from the study.

Results: The most common lesions were avascular, hyalinised, infarcted villi, perivillous and intervillous fibrin deposition, thrombosis of umbilical cord artery and congestion. Thrombosis of chorionic vessels were seen in 5 cases (Mean 0.55, 55.55%). Intervillous thrombosis was seen in 5 cases (Mean 0.55, 55.55%) and chorangiosis was seen in three cases (Mean 0.33, 33.3%). One case of acute chorioamniotis and intervillositis (Mean 0.11, 11.11%) with neutrophilic infiltrate was present, which was confirmed by applying immunohistochemistry with Myeloperoxidase (MPO) stain.

Conclusion: In this study, histological changes are seen in nine placentas of COVID-19 affected women, which showed evidence of thrombosis and associated changes. Although new-borns did not show any abnormality, significant histological changes observed, warrant the risk to fetuses like still birth and miscarriages. Further studies with large sample size could possibly make these consequences more clear. Also introduction of treatment like anti thrombotic therapy may be considered to overcome placental changes to avoid their harmful effects.

Downloads

Download data is not yet available.
Published
2020-09-02
How to Cite
Waqar, S., Saadia, A., Abbas, Z., Akhtar, F., Choudry, A., & Baig, J. (2020). HISTOPATHOLOGICAL CHANGES IN PLACENTAL TISSUE OF COVID–19 PREGNANT WOMEN DELIVERED AT PAK EMIRATE MILITARY HOSPITAL, RAWALPINDI. PAFMJ, 70(2), S434-38. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/5223
Section
Original Articles

Most read articles by the same author(s)

1 2 > >>