Pattern of Different Immunohistochemical Stains in Various Types of Hepatoblastoma

Authors

  • Hina Maqbool Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Sajid Mushtaq Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Mudassar Hussain Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Umer Nisar Sheikh Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Usman Hassan Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Saud Sarwar Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Maryam Hameed Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Mohammad Tariq Mehmood Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Asad Hayat Ahmad Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan

DOI:

https://doi.org/10.51253/pafmj.v72i2.5182

Keywords:

Hepatoblastoma, Immunohistochemical stains, Liver neoplasm

Abstract

Objective: To assess the utility of four immunohistochemical stains in the categorization of hepatoblastoma.

Study Design: Retrospective longitudinal study.

Place and Duration of Study: Histopathology Department, Shaukat Khanum Memorial Cancer Hospital, Peshawar Pakistan, from 2016 to 2018.

Methodology: We retrospectively reviewed 50 cases of hepatoblastoma from 2016-2018, from our hospital database and studied the pattern of four immunohistochemical stains (Beta-catenin, Glutamine synthetase, Heppar 1 and Cyclin D1) in various subtypes.

Results: Ten out of fifty cases were mixed epithelial and mesenchymal hepatoblastomas, and forty were pure epithelial. In the pure epithelial category, the fetal subtype showed Heppar 1 and Cyclin D1 positivity in twenty-eight cases, while Glutamine synthetase and Beta-catenin were positive in all the thirty cases. One case of embryonal subtype displayed negativity for Heppar 1; the rest of the immunohistochemical stains were positive. Ten tumours exhibiting mixed epithelial and mesenchymal morphology showed positivity for all the four immunohistochemical stains in the epithelial component. However, Heppar 1 and cyclin D1 were negative in the mesenchymal component in all the ten cases. Five cases (50%) showed Glutamine synthetase and Beta-catenin positivity in the mesenchymal component.

Conclusion: All the four immunohistochemical stains, especially Beta-catenin and Glutamine synthetase, were efficient diagnostic tool, especially for tumours with complex or vague morphological features.

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Published

28-04-2022

Issue

Section

Original Articles

How to Cite

1.
Maqbool H, Mushtaq S, Hussain M, Sheikh UN, Hassan U, Sarwar S, et al. Pattern of Different Immunohistochemical Stains in Various Types of Hepatoblastoma. Pak Armed Forces Med J [Internet]. 2022 Apr. 28 [cited 2024 Jun. 18];72(2):363-66. Available from: https://pafmj.org/PAFMJ/article/view/5182