LIPID-LOWERING EFFICACY OF 20 MG SIMVASTATIN VERSUS 5 MG ROSUVASTATIN IN PATIENTS OF TYPE 2 DIABETES

  • Hafiz Muhammad Yasir Rehman Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Abdul Latif Khattak Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Taimoor Ashraf Khan Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Abdul Moueed Tariq Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Shahzeb Ahmed Satti Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Rafi Ud Din Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Keywords: HMG-CoA reductase inhibitor, Lipid-lowering efficacy, Low-density lipoprotein cholesterol, Rosuvastatin, Simvastatin, Type 2 diabetes mellitus (T2DM)

Abstract

Objective: To compare the efficacy of Rosuvastatin 5mg and Simvastatin 20mg in reducing low-density lipoprotein cholesterol in newly diagnosed patients with type 2 diabetes.

Study Design: Quasi-experimental study.

Place and Duration of Study: Department of General Medicine, Pak Emirates Military Hospital (PEMH), Rawalpindi, from Jul 2017 to Jan 2018.

Methodology: Patients of type 2 diabetes with hypercholesterolemia (mean LDL-C levels >100 mg/dl) were included in the study. In a sample of 100 patients, half of the patients were in the Rosuvastatin 5mg group (group A) while half patients were in the Simvastatin 20mg group (group B). Non-probability consecutive sampling was done. We followed up the patients for 6 weeks. All the laboratory investigations were performed from the laboratory of the same hospital. Investigator himself recorded all the information including name, age, gender, weight, LDL-C levels, Renal function test reports and CK-MB levels in a self-designed, self-administered proforma. Data were analyzed with statistical analysis program SPSS V 23.

Results: Age range in this study was from 35 to 60 years with a mean age of 46.980 ± 6.31 years in group A vs 48.520 ± 5.61 years in group B. Mean LDL-C Levels were 149.460 ± 25.76 mg/dl in group A vs 146.960 ± 22.92 mg/dl in group B. Mean weight was 82.880 ± 9.17 kg in group A vs 88.660 ± 10.33kg in group B. Male gender was dominant in both group (70% and 72%). In group A, efficacy was seen in 40 (80%) patients as compared to 24 (48%) patients in group B (p<0.001).

Conclusion: Rosuvastatin 5mg tablet was more effective than Simvastatin 20mg in reducing low-density lipoprotein cholesterol in newly diagnosed type 2 diabetes patients.

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Published
2020-08-19
How to Cite
Rehman, H. M., Khattak, A., Khan, T., Tariq, A., Satti, S., & Din, R. (2020). LIPID-LOWERING EFFICACY OF 20 MG SIMVASTATIN VERSUS 5 MG ROSUVASTATIN IN PATIENTS OF TYPE 2 DIABETES. Pakistan Armed Forces Medical Journal (PAFMJ), 70(4), 885-89. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/5050
Section
Original Articles

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