EFFICACY OF SALBUTAMOL DELIVERED THROUGH A METERED DOSE INHALER & SPACER IN CHILDREN WITH ACUTE EXACERBATION OF ASTHMA

Ali Mujtaba Tahir; Waqas Akhtar; Salah Ud Din Balooch; Waqas Ahmed; Ali Murtaza Samar; Amina Sohail

doi:10.51253/pafmj.v71i2.4388

Authors

Ali Mujtaba Tahir Combined Military Hospital Zhob/National University of Medical Sciences (NUMS) Pakistan
Waqas Akhtar Combined Military Hospital Chhor/National University of Medical Sciences (NUMS) Pakistan
Salah Ud Din Balooch Combined Military Hospital Kharian/National University of Medical Sciences (NUMS) Pakistan
Waqas Ahmed Combined Military Hospital Dera Ismail Khan/National University of Medical Sciences (NUMS) Pakistan
Ali Murtaza Samar Salisbury District Hospital NHS Trust, England
Amina Sohail Combined Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v71i2.4388

Keywords:

Asthma exacerbation, Clinical asthma score, Metered dose inhaler, Salbutamol, Spacer

Abstract

Objective: To assess efficacy of salbutamol delivered through metered dose inhaler (MDI) - spacer in paediatric patients with acute exacerbation of asthma.

Study Design: Prospective observational study.

Place and Duration of Study: Department of Paediatrics, Pakistan Naval Ship, Shifa Hospital, Karachi-Pakistan, from Jan to Dec 2018.

Methodology: Ninety Five patients aged ≥6 to ≤12 years, with acute asthma exacerbation were enrolled. Any patient with fever, clinical asthma score (CAS) >7, on home treatment with drugs delivered through nebulization or on oral steroids was excluded. Clinical asthma score recorded on presentation, followed with salbutamol via Metered Dose Inhaler & spacer at dose of 400 µgm (4 x puffs of 100 µgm). Clinical asthma score rechecked after 20 min. Response to salbutamol was then compared in relation to the presenting Clinical asthma score.

Results: Out of 95 children, 45 (47.9%) were male & 50 (52.1%) female with 67.4% having positive family history for asthma. Average premedication clinical asthma score was 2.44. Sixty nine (72.9%) patients had an adequate response as they exhibited clinical asthma score of 0 or fall in score of ≥2. Patients with adequate response had average clinical asthma score of 2.07 on presentation in contrast to 3.42 with inadequate response.

Conclusion: Salbutamol delivered via Metered Dose Inhaler & spacer at dose of 400 µgm is an effective medication for quick relief in children with acute exacerbation of asthma. Moreover, its administration at a point where exacerbation is not much severe steers us towards more favourable outcome.