TAURINE SUPPLEMENTATION NORMALIZES SKELETAL MUSCLE FUNCTIONS IN TYPE 2 DIABETES RATS

  • Amina Rasul Al-Razi Medical College, Peshawar Pakistan
  • Nadia Latif Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Sajid Ali Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Mehvish Ashfaq HITEC Institute of Medical Sciences, Taxilla/National University of Medical Sciences (NUMS) Pakistan
  • Sadia Mubarak Islamabad Medical & Dental College, Islamabad Pakistan
  • Irum Rehman Margalla Institute of Health Sciences, Rawalpindi Pakistan
Keywords: Maximum fused tetanic tension, Maximum fused tetanic tension after fatigue protocol, Taurine

Abstract

Objective: To study effect of supplementation of taurine on force frequency relationship and fatigue of rodent skeletal muscles in type 2 diabetes mellitus.

Study Design: Laboratory-based experimental study.

Place and Duration of Study: Department of Physiology at Army Medical College Rawalpindi, from Apr 2013 to Jun 2013.

Methodology: Ninety Sprague-Dawley rats were divided randomly in to 3 groups; control (group-1), beta-alanine (group-2), and taurine group (group-3). All rats were fed with taurine free-high fat diet and administered streptozocin to induce type 2 diabetes mellitus. In addition, group-1 was supplemented with 0.02% (w/v) taurine, group-2 with 3% (w/v) beta-alanine, and group-3 with 3% (w/v) taurine in their respective drinking water. At 21st day, plasma glucose and insulin resistance were measured to affirm type-II diabetes mellitus in all groups. At 28th day, contractile functions of extensor digitorum longus muscles at high frequencies were evaluated using i Worx data acquisition unit (AHK/214).

Results: The decline in maximum fused tetanic tension, maximum fused tetanic tension after fatigue protocol, and recovery from fatigue was significantly ameliorated in taurine supplemented diabetic rats.

Conclusion: Taurine supplementation significantly improved the contractile functions of diabetic rodent skeletal muscle at high frequency stimulation.

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Published
2020-02-29
How to Cite
Rasul, A., Latif, N., Ali, S., Ashfaq, M., Mubarak, S., & Rehman, I. (2020). TAURINE SUPPLEMENTATION NORMALIZES SKELETAL MUSCLE FUNCTIONS IN TYPE 2 DIABETES RATS. Pakistan Armed Forces Medical Journal, 70(1), 224-29. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/3967
Section
Original Articles