COMPARISON OF PERIOPERATIVE USE OF TRANEXAMIC ACID WITH PLACEBO IN PATIENTS WITH HIP FRACTURES IN TERMS OF FREQUENCY OF DEEP VENOUS THROMBOSIS

  • Hafiz Muhammad Yaqoob Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Abdul Qadir Khan Federal General Hospital, Islamabad Pakistan
  • Muhammad Jameel Holy Family Hospital, Rawalpindi Pakistan
  • Naveed Ullah Khan Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Syed Asim Sherazi Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Zeeshan Khan Gomal Medical College, Dera Ismail Khan Pakistan
Keywords: Deep vein thrombosis, Hip fractures, Tranexamic acid

Abstract

Objective: To compare perioperative use of tranexamic acid with placebo in patients with hip fractures in terms of frequency of deep venous thrombosis.

Study Design: Quasi experimental study.

Place and Duration of Study: CMH Orthopedics department Rawalpindi, from Apr 2017 to Oct 2017.

Methodology: A total of 306 patients presenting with hip fracture, 50 to 90 years of age were included. Patients with Hip fractures presenting with sepsis, hypercoagulable state, pregnancy and breast feeding and contra-indication to tranexamic acid were excluded. The sample size was divided into two equal groups by lottery method, Tranexamic Acid (TXA) and Placebo. The patient was followed till 15th post op day for the purpose of study and at 15th post op day a Doppler ultrasound was performed on both lower limbs and presence or absence of deep venous thrombosis was recorded.

Results: The mean age of patients in group A (tranexamic acid group) was 70.80 ± 11.13 years and in group B (placebo group) was 71.50 ± 11.30 years. Out of these 306 patients, 215 (70.26%) were male and 91 (29.74%) were females. Deep venous thrombosis was seen in 31 patients in group A (tranexamic acid group) and 14 patients in group B (placebo group) with p-value of 0.006.

Conclusion: Frequency of deep venous thrombosis was observed more in patients receiving perioperative intravenous tranexamic acid as compared to control.

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Published
2020-02-28
How to Cite
Yaqoob, H., Khan, A., Jameel, M., Khan, N., Sherazi, S., & Khan, Z. (2020). COMPARISON OF PERIOPERATIVE USE OF TRANEXAMIC ACID WITH PLACEBO IN PATIENTS WITH HIP FRACTURES IN TERMS OF FREQUENCY OF DEEP VENOUS THROMBOSIS. Pakistan Armed Forces Medical Journal, 70(1), 68-72. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/3937
Section
Original Articles

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