HAEMOSTATIC ROLE OF TRANEXAMIC ACID IN ENDOSCOPIC SINUS SURGERY– AN INTERVENTIONAL STUDY

Abstract

Objective: To compare preoperative intravenous tranexamic acid with placebo in terms of operative estimated blood loss, in patients undergoing endoscopic sinus surgery.

Study Design: Quasi experimental study. Place and Duration of Study: Department of ENT, CMH Peshawar, from Jan 2017 to Jun 2017.

Methodology: Patients were divided into 2 groups by lottery method. The case group received intravenous tranexamic acid 15mg/kg body weight in 100 ml of normal saline and the control group received 100 ml of normal saline only in identical syringes 15 minutes before start of surgery. At the end of surgery intraoperative hemorrhage was estimated by estimating for blood loss based on the contents of suction container after subtracting the irrigation fluid and the nasopharyngeal packing measurement via electronic scale (1ml of blood weighs 1 gram).

Results: In our study, 30 (46.15%) in case group and 37 (56.92%) in control group were between the age of 18-30 years whereas 35 (53.85%) in case group and 28 (43.08%) in control group were between the age of 31-50 years. Mean ± SD was calculated as 32.0 ± 6.29 in case group and 31.78 ± 6.59 years in control group, 34 (52.31%) in case group and 29 (44.62%) in control group were males while 31 (47.69%) in case group and 36 (55.38%) in control group were females. Evaluation of mean blood loss in both groups was done, it shows 104.15 ± 3.44 ml in case group and 184.32 ±10.14 ml in control group, p-value was 0.0001.

Conclusion: We concluded that preoperative intravenous tranexamic acid significantly reduces operative estimated blood volume loss when compared to placebo in patients undergoing endoscopic para nasal sinus surgical procedures.