Frequency of Hyperuricemia in Type-2 Diabetes Mellites and its Relation with Diabetic Nephropathy

Authors

  • Gulzar Ali Combined Military Hospital Peshawar/National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Asif Kamran 64 Medical Battalion Field Hospital, Miran-Shah Pakistan
  • Muhammad Amir Combined Military Hospital Peshawar/National University of Medical Sciences (NUMS) Pakistan
  • Babar Mumtaz Combined Military Hospital Peshawar/National University of Medical Sciences (NUMS) Pakistan
  • Imran Khan Combined Military Hospital Peshawar/National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Tariq Combined Military Hospital Peshawar/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i1.3916

Keywords:

Diabetes mellitus, Diabetic nephropathy, Hyperuricemia, Microalbuminuria

Abstract

Objectives: To determine the frequency of Hyperuricemia in patients with type-2 Diabetes Mellitus and to compare frequency of Diabetic Nephropathy in Hypouricemic vs Normouricemic patients with type-2 Diabetes.

Study Design: Cross-sectional analytical study.

Duration and Place of Study: Medicine Department Combined Military Hospital Peshawar, from Dec 2018 to May 2019.

Methodology: Patients from both genders with type 2 Diabetes having glycosylated hemoglobin (HbA1c) ≥6.5%, Fasting Blood glucose ≥ to 7.0 mmol/L or random blood glucose ≥11.1 mmol/L were recruited from out Patient department.Participants were tested for serum uric acid, fasting blood glucose, Glycosylated hemoglobin (HbA1c) and Spot Urine Albumin Creatinine Ratio after 8 hours fasting.

Results: Out of 111 patients enrolled Hyperuricemia was present in 40 (36.04%) patients of which 21 (52.50%) were male and 19 (47.50%) were female. Diabetic Nephropathy was present in 43(38.74%). Out of 43 patients having diabetic nephropathy, 25 (58.14%) were having hyperuricemia. The study observed a linear relationship between serum uric acid and type-2 diabetes duration, fasting blood glucose levels, glycosylated hemoglobin (HbA1c) and urinary Albumin creatinine ratio.

Conclusion: Hyperuricemia is positively linked with diabetic complications in majority of patients with type-2 diabetes. Serum uric acid levels can be used as an early diagnostic parameter and can prognosticate diabetic nephropathy.
Keywords: Diabetes mellitus, Diabetic nephropathy, Hyperuricemia, Microalbuminuria

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Published

28-02-2023

How to Cite

1.
Ali G, Kamran MA, Amir M, Mumtaz B, Khan I, Tariq M. Frequency of Hyperuricemia in Type-2 Diabetes Mellites and its Relation with Diabetic Nephropathy. Pak Armed Forces Med J [Internet]. 2023 Feb. 28 [cited 2024 May 25];73(1):199-203. Available from: https://pafmj.org/PAFMJ/article/view/3916

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