CLINICO-PATHOLOGICAL FEATURES IN PATIENTS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH DEL 11q22

Abstract

Objective: To determine the frequency of DEL 11q22 in patients of Chronic Lymphocytic Leukemia and clinico-pathological features in Chronic Lymphocytic Leukemia with DEL 11q22.

Study Design: Cross sectional analytical study.

Place and Duration of Study: Department of Hematology, Armed Forces Institute of Pathology Rawalpindi, from Apr 2017 to Jul 2018.

Methodology: A total of 61 newly diagnosed cases of Chronic Lymphocytic Leukemia were included. Diagnosis was made according to National Cancer Institute Working Group guidelines for diagnosis of Chronic Lymphocytic Leukemia. After relevant history and clinical examination; complete blood counts, biochemical profile, bone marrow examination, immunophenotyping on bone marrow or peripheral blood samples and Interphase FISH studies on blood or bone marrow specimens for detection of DEL 11q22 were carried out.

Results: Deletion 11q22 was detected in 7 (11.4%) of Chronic Lymphocytic Leukemia patients. Median white cell count was 152 x 109/L (74-156) and absolute lymphocyte count was 105.5 x 109/L (74-139) which was higher than patients of Chronic Lymphocytic Leukemia without DEL 11q22. According to Rai staging, 3 (42.9%) patients presented in advanced stage Rai III and 2 (28.6%) patients were in Rai I & Rai II. All patients of Chronic Lymphocytic Leukemia with DEL 11q22 presented with B-symptoms and lymphadenopathy. Bulky disease was found in 2(28.5%) of patients. CD38 expression was in 3 (42.8%) cases.

Conclusion: Frequency of DEL 11q22 in Chronic Lymphocytic Leukemia in our population was found to be 11.4%. All patients of Chronic Lymphocytic Leukemia with DEL 11q22 presented with B-Symptoms and lymphadenopathy.