MELIORATIVE EFFECT OF COMMERCIAL GREEN TEA ON IBUPROFEN INDUCED HISTOMORPHOLOGICAL ALTERATION IN LUMINAL DIAMETER OF PROXIMAL RENAL TUBULE

  • Afnan Gul Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Ayesha Asad Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Saima Sohail Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Khadija Qamar Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: Catechins, Ibuprofen, Proximal tubule

Abstract

Objective: To study the effects of commercial green tea on ibuprofen induced effects on luminal diameter of proximal renal tubule in adult rat.

Study Design: Laboratory based experimental study.

Place and Duration of Study: Army Medical College Rawalpindi and National Institute of Health (NIH) Islamabad, from Mar 2017 to May 2017.

Methodology: Thirty healthy adult Sprague Dawley rats were divided into three groups, each containing 10 animals. Schedule of intervention was once a day for a period of 8 weeks. Group Awascontrol. Group B received only ibuprofen 120 mg/kg bodyweight once daily. Group C was given green tea 1ml/100 mg bodyweight in addition to ibuprofen 120mg/kg bodyweight, once a day. At the end of 8 weeks, all animals were sacrificed and kidneys were dissected out. Renal tissue was then prepared for histological study. Luminal diameters of proximal renal tubules were measured.

Results: Luminal diameter of proximal renal tubule was found significantly reduced (4.79 ± 0.92μm) in experimental group B (ibuprofen only), as compared to those in control group A (13.073 ± 1.02μm) and in experimental group C (12.67 ± 1.34μm). However, the reduction in proximal luminal diameter in group C was not significant as compared to group A.

Conclusion: Ibuprofen caused reduction in proximal luminal diameter in kidneys of adult rats. However, administration of green tea along with ibuprofen protects against the adverse effects of the drug.

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Published
2020-01-27
How to Cite
Gul, A., Asad, A., Sohail, S., & Qamar, K. (2020). MELIORATIVE EFFECT OF COMMERCIAL GREEN TEA ON IBUPROFEN INDUCED HISTOMORPHOLOGICAL ALTERATION IN LUMINAL DIAMETER OF PROXIMAL RENAL TUBULE. Pakistan Armed Forces Medical Journal, 70(Suppl-1), S6-9. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/3784
Section
Original Articles

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