FREQUENCY OF INCREASED PLASMA C-PEPTIDE LEVELS IN COLORECTAL CANCER PATIENTS

Muhammad Hasan Saleem; Shazia Nisar; Muhammad Zulqurnain Saleem; Husnain Saleem; Shoaib Mukhtar; Muhammad Anjum

doi:10.51253/pafmj.v71i6.3685

Authors

Muhammad Hasan Saleem Combined Military Hospital Kharian/National University of Medical Sciences (NUMS) Pakistan
Shazia Nisar Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Muhammad Zulqurnain Saleem Combined Military Hospital Kharian/National University of Medical Sciences (NUMS) Pakistan
Husnain Saleem Combined Military Hospital Peshawar/National University of Medical Sciences (NUMS) Pakistan
Shoaib Mukhtar Armed Forces Institute of Rehabilitation Medicine/ National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Muhammad Anjum Combined Military Hospital Kharian/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v71i6.3685

Keywords:

Colorectal cancer, C-peptide, dense energy, IGF binding protein-1

Abstract

Objective: To assess the increased frequency of serum C-peptide levels in patients of colorectal carcinoma.

Study Design: Cross sectional study.

Place and Duration of Study: Combined Military Hospital, Rawalpindi Pakistan, from Jul 2018 to Jan 2019.

Methodology: A total of 100 cases of colorectal carcinoma were enrolled. Blood samples were obtained to assess C-peptide level. The C-peptide serum concentrations were deliberate through the Cobas 6000 by using the electro-chemi-luminescence immunoassay (ECLIA) method. If level of C-peptide was >2 pmol/mL, then it was noted.

Results: The mean age of all patients was 58.3 ± 5.4 years. There was a total of 136 (68%) females and 64 (32%) were males. The mean BMI of patients was 28.96 ± 12.31 kg/m2. The family history of colorectal carcinoma was positive in 6 (6%) cases. The mean C-peptide level was 4.55 ± 2.37 pmol/L. There were 33 (33%) patients with raised C-peptide level while 67 (67%) had normal c-peptide level.

Conclusion: It is concluded that increased C-peptide level is high in patients with colorectal cancer.