ASSOCIATION OF ANTHROPOMETRIC AND BIOCHEMICAL PARAMETERS WITH NONALCOHOLIC FATTY LVER DISEASE

Abstract

Objective: To study the association of anthropometric and biochemical parameters with nonalcoholic fatty liver disease (NAFLD) diagnosed on ultrasonography (USG).

Study Design: Cross sectional analytical study.

Place and Duration of Study: Department of Pathology, Combined Military Hospital (CMH) Mardan, from Aug 2016 to Jan 2017.

Methodology: Study was conducted on 96 individuals 20-65 years enrolled by non-probability consecutive sampling. They were evaluated by taking anthropometric and biochemical parameters to establish association of nonalcoholic fatty liver disease diagnosed on ultrasonography as compared to healthy individuals.

Results: Mean age was 28.7 ± 10.3 years in control group as compare to 39.9 ± 10.8 years in nonalcoholic fatty liver disease group. Nonalcoholic fatty liver disease was seen in 17 (28%) females as compared to 44 (72%) males showing strong association of males with the disease (p=0.025). There were 31 (50%), 22 (36%) and 8 (14%) cases in mild, moderate and severe nonalcoholic fatty liver disease categories respectively using ultrasonography. Abdominal circumference, systolic blood pressure and body mass index (BMI) were significantly associated with nonalcoholic fatty liver disease. Whereas, among biochemical parameters serum glucose, alanine amino-transferase (ALT), triglyceride and low density lipoprotein cholesterol (LDL-C) were independent parameters strongly associated with nonalcoholic fatty liver disease.

Conclusion: Our study showed that deranged anthropometric along with biochemical parameters was strongly associated with development of nonalcoholic fatty liver disease.