CORELATION OF SERUM URIC ACID LEVELS WITH MODIFIED RANKIN SCORE IN PATIENTS WITH ACUTE ISCHEMIC STROKE
Objective: To determine the correlation of mean serum levels of uric acid with mean modified Rankin score at 72 hours in patients with acute ischemic stroke.
Study Design: Correlational study.
Place and Duration of Study: Department of Medicine, Benazir Bhutto Hospital Rawalpindi, from Oct 2016 to Apr 2017.
Methodology: Total of 40 ischemic stroke patients, aged 15 to 85 years were selected after fulfilling the inclusion criteria. Serum uric acid levels were obtained within 24 hours of admission. Functional outcome was measured after 72 hours by modified Rankin Scale. The data was analyzed by SPSS version 23. Pearson correlation coefficient was calculated between mean SUA levels and mean MRS. p-value of ≤0.05 was considered significant.
Results: Mean age was 66.53 ± 12.20 years. 19 (47.5%) patients were males. The SUA was 4.78 ± 1.46 mg/dl while MRS was 3.15 ± 1.72. Poor outcome (MRS ≥3) was noted in 22 (55%) patients. Out of these, five patients (12.5%) died. The Pearson correlation between SUA and MRS was 0.511 (p=0.001). The correlation was statistically significant for all age and gender groups except female (r=0.363, p=0.106).
Conclusion: Our study results yielded that Serum Uric acid (SUA) levels are correlated with the severity of ischemic stroke.