FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES

  • Sardar Muhammad Bolan University of Health Sciences, Quetta Pakistan
  • Amer Fakhr Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Adnan Manzar Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Farzana Hakim Foundation University Medical College, Islamabad Pakistan
  • Taimoor Ashraf Khan HQ Ghazaband Scouts, Belleli FC Balochistan North
  • Bilal Ahmad ak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: Ankylosing spondylitis, Axial spondylitis, Extra articular manifestation, Human leukocyte antigen B-27 (HLA B-27), Inflammatory markers, Peripheral arthritis, Spondyloarthritis, Uveitis

Abstract

Objective: To determine the frequency of Human leukocyte antigen B-27 patients with clinically diagnosed ankylosing spondylitis and frequency of peripheral joints‟ involvement and serum inflammatory markers (raised serum C-reactive protein & erythrocyte sedimentation rate).

Study Design: Descriptive, cross-sectional study.

Place and Duration of Study: Department of Rheumatology Pak Emirates Military Hospital, Rawalpindi for duration of 10 months from Jan 2018 to Oct 2018.

Methodology: We included 100 cases of Ankylosing Spondylitis. Sample was selected by consecutive sampling technique and used “(Modified) New York Classification Criteria for Ankylosing Spondylitis”. Blood samples for C-reactive protein & erythrocyte sedimentation rate and Human leukocyte antigen B-27 were analysed by the same pathologist. We analyzed the data by using SPSS version 20.

Results: Mean age of cases was 25 ± 4.5 years. Seventy-seven patients were positive for Human leukocyte antigen B27 and 23 were negative. In 69% patients erythrocyte sedimentation rate was high and in 64% patients C-reactive protein was raised. In 33% patient there was only axial involvement while peripheral arthritis was present in 67% of patients and enthesitis in 60%. Only 5% patients have the uveitis (All positive for Human leukocyte antigen B-27). Only one patient had cardiac involvement.

Conclusion: Ankylosing Spondylitis was found a common disease and study results showed similar trends of positive Human leukocyte antigen B-27 cases as in the rest of the world. Human leukocyte antigen B-27 has a strong statistically significant association with peripheral joint involvement and acute anterior uveitis.

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Published
2019-12-18
How to Cite
Muhammad, S., Fakhr, A., Manzar, M., Hakim, F., Khan, T., & Ahmad, B. (2019). FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES. Pakistan Armed Forces Medical Journal, 69(6), 1194-98. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/3632
Section
Original Articles