COMPARISON OF TWO DIFFERENT SPINAL DOSES OF 0.75% BUPIVACAINE CAUSING MATERNAL HYPOTENSION IN ELECTIVE CAESAREAN SECTION

Abstract

Objective: To compare the frequency of maternal hypotension between spinal doses of 7.5 mg and 15 mg of 0.75% hyperbaric bupivacaine in elective caesarean section.

Study Design: Quasi Experimental Study.

Place and Duration of Study: The study was conducted in Department of Anesthesiology, Combined Military Hospital Kharian, from 11th May 2016 to 10thNov 2016.

Methodology: A total of 130 cases were selected for the study and equally divided in two group (A or B) after approval by ethics committee of hospital via using the random numbers table. In group A, 7.5 mg of 0.75% of bupivacaine administered at L3-4 in subarachnoid space after confirmation of CSF withdrawal, while in group B, 15mg of 0.75% of bupivacaine at the same space have been introduced, hence both groups were preloaded with Hartmann’s solution @15ml/kg body weight.

Results: In our study, out of 130 cases (65 in each group), mean age was calculated as 28.97 ± 2.52 years in group- A and 29.15 ± 2.52 years in group-B, frequency of maternal hypotension was recorded as 47 (72.31%) in group-A and 61 (93.85%) in group-B while 18 (27.69%) in group-A and 4 (6.15%) had no hypotension, p-value calculated with 0.001 indicating a significant difference between these groups.

Conclusion: The frequency of maternal hypotension was significantly lower with spinal doses of 7.5 mg and when compared with 15 mg of 0.75% hyperbaric bupivacaine in elective caesarean section.