ROLE OF PERIOPERATIVE ANALGESIA WITH ACETAMINOPHEN IN REDUCING PAIN FOLLOWING ELECTROCONVULSIVE THERAPY

  • Sana Khan Armed Forces Institute of Mental Health/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Rashid Qayyum Armed Forces Institute of Mental Health/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Khalid Buland Armed Forces Institute of Mental Health/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Mehwish Ujala Armed Forces Institute of Cardiology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Usama Bin Zubair Pakistan Institute of Medical Sciences (NUMS) Islamabad Pakistan
Keywords: Electroconvulsive therapy, Headache, Myalgia, Perioperative analgesia, Quasi experimental study

Abstract

Objective: To assess the efficacy of perioperative analgesia with acetaminophen in reducing the occurrence and severity of post-ECT pain.

Study Design: Quasi experimental study.

Study Place and Duration: Tertiary care mental health facility at Rawalpindi, Jun to Nov 2018.

Methodology: Patients of all age groups and either gender for whom elective ECT was recommended during the study time period were included in the study. Acetaminophen (1g/100ml) and placebo (100ml) infusions were infused according to randomized sequence during ECT session. Study participants were assessed for presence and severity of pain i.e. headache and/or myalgia, two hours before and after ECT by using visual analog scale (VAS).

Results: A sum of 146 study participants were randomized to either receive intervention (Group A) or placebo (Group B), both the groups comprised of 73 participants each. The frequency of post-ECT headache and myalgia in group A, who received acetaminophen infusion, was 8.2% and 2.7% respectively as compared to placebo group B where incidence of post-ECT headache and myalgia was reported to be 24.7% and 10.9% respectively (8.2% vs 24.7%, p 0.013 and 2.7% vs 10.9%, p 0.03 respectively). Uni-variate analysis showed that participants in group A were 72.6% less likely to develop post-ECT headache (OR 0.27, 95% CI 0.11-0.73, p 0.007), and 55% less likely to develop post-ECT myalgia (OR 0.45, 95% CI 0.21-0.80, p 0.01) than participants in group B.

Conclusion: Acetaminophen has been found effective in reducing the incidence and severity of headache and myalgia following electroconvulsive therapy.

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Published
2019-10-23
How to Cite
Khan, S., Qayyum, R., Buland, K., Ujala, M., & Zubair, U. (2019). ROLE OF PERIOPERATIVE ANALGESIA WITH ACETAMINOPHEN IN REDUCING PAIN FOLLOWING ELECTROCONVULSIVE THERAPY. Pakistan Armed Forces Medical Journal, 69(5), 943-48. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/3392
Section
Original Articles