Frequency and Pattern of Thyroid Dysfunction in Patients with Polycystic Ovary Syndrome

Sadaf Naz; khurshid Ahmad khan; Amina Umer; Muhammad Tabish Raza; Khalid Mehmood Nasir; Imtiaz Hussain

doi:10.51253/pafmj.v72i5.3288

Authors

Sadaf Naz Allama Iqbal Medical College, Lahore, Jinnah Hospital, Lahore, Pakistan
khurshid Ahmad khan Allama Iqbal Medical College, Lahore, Jinnah Hospital, Lahore, Pakistan
Amina Umer Allama Iqbal Medical College, Lahore, Jinnah Hospital, Lahore, Pakistan
Muhammad Tabish Raza Allama Iqbal Medical College, Lahore, Jinnah Hospital, Lahore, Pakistan
Khalid Mehmood Nasir Allama Iqbal Medical College, Lahore, Jinnah Hospital, Lahore, Pakistan
Imtiaz Hussain Allama Iqbal Medical College, Lahore, Jinnah Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.51253/pafmj.v72i5.3288

Keywords:

Anti-TPO, Polycystic ovarian syndrome, Thyroid autoimmunity, Thyroid dysfunction

Abstract

Objective: To determine the frequency and pattern of thyroid dysfunction in patients with polycystic ovary syndrome.

Study Design: Cross-sectional study.

Place and Duration of Study: Department of Endocrinology, Jinnah Hospital, Lahore Pakistan, from Jan from Jun 2017.

Methodology: Seventy-seven patients diagnosed with PCOS, based on Rotterdam criteria, were enrolled in the study. Thyroid function status was evaluated using measurement of serum thyroid-stimulating hormone (TSH), free T3, T4 and anti-thyroperoxidase (anti-TPO) antibodies.

Results: The mean age of the study population was 29.0±9.2 years. Out of 77 females with PCOS, 63(81.8%) were euthyroid, five (6.5%) patients were diagnosed with primary hypothyroidism, and nine (11.7%) were found to have subclinical hypothyroidism. Anti-TPO antibodies were detected in 18 patients (23.4%), including 12(19.0%) euthyroid females.

Conclusion: Thyroid dysfunction was found among patients with PCOS. Evidence of autoimmunity was seen even in euthyroid patients.