COMPARISION OF PRE-OPERATIVE ON DANSETRON VERSUS COMBINATION OF DEXAMETHASONE AND ONDANSETRON FOR POSTOPERATIVE NAUSEA
To compare the efficacy of ondansetron with a combination of ondansetron and dexamethasone after elective laparoscopic cholecystectomy in terms of postoperative nausea and vomiting.
Study Design: Randomized controlled trial.
Place and Duration of Study: Department of Surgery, Combined Military Hospital Rawalpindi Pakistan, from Apr 2014 to Mar 2015.
Materials and Methods:
Two hundred and twenty two patients fulfilling the inclusion criteria were selected for study and divided into two groups of 111 each. Group A was given ondansetron while group B was given combination of ondansetron and dexamethasone at induction of general anesthesia. Patients of both groups were observed at 24 hours postoperatively for nausea and vomiting.
Sixty six patients in group A had nausea as compared to 50 patients in group B (p-value 0.03), 46 patients in group A had vomiting as compared to 19 patients in group B (p-value <0.001), showing statistically significant difference between the two groups.
Postoperative nausea and vomiting is significantly lower in ondansetron and dexamethasone combination group as compared to ondansetron alone group after elective laparoscopic cholecystectomy.