Comparison of Procalcitonin Versus C Reactive Protein in The Detection of Neonatal Sepsis

Authors

  • Wahid Ali Pakistan Institute of Medical Sciences, Islamabad Pakistan
  • Haider Shirazi Pakistan Institute of Medical Sciences, Islamabad Pakistan
  • Shireen Gul Pakistan Institute of Medical Sciences, Islamabad Pakistan
  • Alia Halim Pakistan Institute of Medical Sciences, Islamabad Pakistan
  • Qurat-ul Ain POF Hospital, Wah Cantt Pakistan
  • Qaiser Zaman Pakistan Institute of Medical Sciences, Islamabad Pakistan

DOI:

https://doi.org/10.51253/pafmj.v72i1.2478

Keywords:

Neonatal sepsis, C Reactive Protein, Early diagnosis, Procalcitonin

Abstract

Objective: To compare procalcitonin and C-reactive protein in the detection of neonatal sepsis keeping blood culture as gold standard.

Study Design: Cross sectional study.

Place and Duration of Study: Neonatal Intensive Care Unit, Children Hospital, Pakistan Institute of Medical Sciences, Islamabad, from Jul to Dec 2018.

Methodology: Neonates up to 28 days of age with the suspicion of sepsis were selected. All the patients with congenital malformation were excluded. Two bed-sided tests i.e., procalcitonin and C-reactive protein was performed using standardized laboratory methods. The diagnostic strength of both tests was compared.

Results: A total of 154 neonates were enrolled in this study. Male neonates were dominant in this study 95 (61.7%). The mean age of patients was 6.1 ± 3.8 days. C reactive protein had a sensitivity and specificity of 50.9% and 28.7% respectively. While procalcitonin was found to have a comparatively high sensitivity and specificity 73.6% and 38.6% respectively. On blood culture test; klebsiella pneumoniae, pseudomonas, staphylococcus aureus were found out to be the most common pathogens.

Conclusion: Procalcitonin has a better sensitivity and specificity than C reactive protein in the diagnosis of early neonatal sepsis.

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Published

28-02-2022

How to Cite

Ali, W., Shirazi, H., Gul, S., Halim, A., Ain, Q.- ul, & Zaman, Q. (2022). Comparison of Procalcitonin Versus C Reactive Protein in The Detection of Neonatal Sepsis. Pakistan Armed Forces Medical Journal, 72(1), 131–35. https://doi.org/10.51253/pafmj.v72i1.2478

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Section

Original Articles