EFFECT OF SMOKING IN INTERLEKIN-6 IN SPRAGUE DAWLEY RATS

Effect of Smoking

  • Aneela Jamil Foundation University Medical College Islamabad Pakistan
  • Amir Rashid Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Abdul Khaliq Naveed Riphah International University Islamabad Pakistan

Abstract

Objective: To investigate the effect of cigarette smoking on interleukin-6 in Sprague Dawley rats.
Study Design: Randomized controlled study.
Place and Duration of Study: Study was conducted at Army Medical College Rawalpindi, from Jan to Apr 2015.
Material and Methods: Seventy healthy male Sprague Dawley rats were randomly divided into two groups at National Institute of Health (NIH). Group-I rats were not exposed while group-II rats were exposed to cigarette smoke for 3 months. Interleukin-6 (IL-6) was determined using commercially available enzyme linked immunosorbent assay (ELISA) kit. Data was analyzed using t-test.
Results: Higher levels of IL-6 were observed in exposed than in non-exposed. The mean of IL-6 levels of control and smoker groups was 40.84 ± 9.09 and 49.48 ± 19.69 respectively. The difference was statistically significant (p<0.05).
Conclusion: Positive association was found between cigarette smoking and IL-6. This shows that IL-6 may be used as a biochemical marker to assess inflammatory damage in smoke related diseases.

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Published
2018-08-31
How to Cite
Jamil, A., Rashid, A., & Naveed, A. (2018). EFFECT OF SMOKING IN INTERLEKIN-6 IN SPRAGUE DAWLEY RATS. PAFMJ, 68(3), 658-63. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/2107
Section
Original Articles

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