COMPARATIVE EFFICACY OF AMLODIPINE AND HYDROCHLORTHIAZIDE- AMILORIDE IN CASES OF MILD ESSENTIAL HYPERTENSION IN OUTDOOR PATIENTS AT COMBINED MILITARY HOSPITAL MULTAN

Comparative Efficacy of Amlodipine and Hydrochlorthiazide-Amiloride

  • Maj Muhammad Usman Ullah Classified Medical Specialist, 2Mtn Field Ambulance
  • Muhammad Babar Khan MH Rawalpindi
  • Muhammad Tahir PAF Hospital Islamabad
  • Wasim Alamgir CMH Multan
  • Muhammad Ali Yousaf 130 Fd Amb
  • Asif Hashmat CMH Dera Nawab Sahib
  • Manzoor Qadir PAF Hospital Islamabad
Keywords: Mild essential hypertension, Amlodipine, Hydrochlorothiazide-Amiloride

Abstract

Objectives: To compare antihypertensive effect of fixed dose combination HydrochlorothiazideAmiloride and Amlodipine in patients of mild essential hypertension. Study Design: Randomized controlled trial (RTC) Place and Duration of Study: Department of Medicine Combined Military Hospital Multan Cantt from 29 January 2007 to 29 June 2007. Patients and Methods: After fulfilling the inclusion criteria of mild essential hypertension, defined as per recommendations of Seventh Joint National Committee (JNC 7) for treatment of Hypertension as stage 1 hypertension, systolic blood pressure (SBP) ≥ 140-159-mmHg and Diastolic blood pressure(DBP) ≥ 90-99-mmHg, 100 patients were randomized into two study groups using a table of random numbers. Group 1 received tab amlodipine (5 mg) and Group 2 received tab hydrocholrthiazide-amiloride (25 mg-2.5mg). Informed written consent was taken. The patients were followed on subsequent visits (6 in total) for five months and systolic and diastolic blood pressure was recorded carefully. All the data thus obtained were processed and analyzed using SPSS version 10.0. Mean and standard deviation (SD) were calculated for age, diastolic and systolic blood pressure. Results: In group 1 the drop in mean SBP between first and last visit was 15.42 mm Hg. In group 2 the drop in mean SBP between first and last visit was 18.34 mm Hg. In group 1, the drop in mean DBP between first and last visit was 10.08 mm Hg. In group 2 the drop in mean DBP between first and last visit was 14.65 mmHg. Mean drop in SBP of both the groups were compared with each other and found to be significantly different (P=0.003). Similarly mean drop in DBP of both the groups were compared with each other and found to be significant statistically (P=0.001).

Conclusion: Hydrochlorothiazide-Amiloride had significantly better antihypertensive effect than Amlodipine in patients of mild essential hypertension at the end of five months therapy.

Downloads

Download data is not yet available.
Published
2010-03-31
How to Cite
Ullah, M. M., Khan, M., Tahir, M., Alamgir, W., Yousaf, M., Hashmat, A., & Qadir, M. (2010). COMPARATIVE EFFICACY OF AMLODIPINE AND HYDROCHLORTHIAZIDE- AMILORIDE IN CASES OF MILD ESSENTIAL HYPERTENSION IN OUTDOOR PATIENTS AT COMBINED MILITARY HOSPITAL MULTAN. Pakistan Armed Forces Medical Journal, 60(1), 37-41. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/169
Section
Original Articles

Most read articles by the same author(s)