EVALUATION OF CHRONIC KIDNEY DISEASE PATIENTS FOR INSULIN RESISTANCE IN TERTIARY CARE HOSPITAL

Chronic Kidney Disease & Insulin Resistance

  • Dr Sufyan Tahir Department of Chemical Pathology, Army Medical College Rawalpindi Pakistan
  • Asma Hayat Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Saleem Ahmed Khan Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Tariq Mahmood Ahmad Army Medical College Rawalpindi, National University of Science and Technology (NUST)
  • Saqibah Rehman Army Medical College Rawalpindi, National University of Science and Technology (NUST)
  • Numan Majeed Army Medical College Rawalpindi, National University of Science and Technology (NUST)
Keywords: Chronic kidney disease, Hypertriglyceridemia, HOMA-IR, Insulin resistance

Abstract

Objective: To evaluate the patients of chronic kidney disease for insulin resistance.
Study Design: Cross sectional observational study.
Place and Duration of Study: The study was conducted in the chemical pathology department of Army Medical
College/Military Hospital Rawalpindi, from Nov 2016 to Apr 2017.
Material and Methods: Fifty patients were recruited for this study with deranged renal functions and/or having
any structural renal abnormality for more than 3 months. These patients did not have any history of diabetes and
dialysis. Fifty ages matched healthy individuals were included as controls. Renal function tests, lipid profile,
complete blood count, fasting plasma glucose and serum insulin levels were performed in all subjects. Insulin
resistance was calculated by using homeostatic model for assessment of insulin resistance (HOMA-IR). Results of
this study were analyzed on SPSS version 23.
Results: Fasting insulin levels were much higher in the patient with chronic kidney disease as compared to
controls (p-value=0.001). HOMA-IR in cases was also significantly higher. Statistical comparison of lipid profile
showed significant difference of only triglycerides level.
Conclusion: HOMA-IR is markedly raised in the patients of chronic kidney disease. This indicates a significant
association of chronic kidney disease with insulin resistance.

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Published
2018-02-28
How to Cite
Tahir, D. S., Hayat, A., Khan, S., Ahmad, T., Rehman, S., & Majeed, N. (2018). EVALUATION OF CHRONIC KIDNEY DISEASE PATIENTS FOR INSULIN RESISTANCE IN TERTIARY CARE HOSPITAL. Pakistan Armed Forces Medical Journal (PAFMJ), 68(1), 29-33. Retrieved from https://pafmj.org/index.php/PAFMJ/article/view/1560
Section
Original Articles

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