ASSOCIATION OF INFLAMMATORY MARKERS WITH PHYSICAL ACTIVITY, FAMILY HISTORY AND OTHER DIABETIC COMPLICATIONS IN PATIENTS OF DIABETIC RETINOPATHY

Diabetic Complications in Patients of Diabetic Retinopathy

Abstract

Objective: To study the association of inflammatory markers with physical activity, family history and other complications among patients of diabetic retinopathy.
Study Design: Cross sectional comparative study.
Place and Duration of Study: Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi in collaboration with Armed Forces Institute of Ophthalmology (AFIO) and Military Hospital Laboratories, Rawalpindi from Jan 2016 to Jun 2016.
Material and Methods: A total of 90 diagnosed patients of diabetic retinopathy of ages 40-70 years were enrolled from Armed Forces Institute of Ophthalmology, Rawalpindi. Their inflammatory markers (ESR and CRP) were assessed and their levels were compared with their physical activity, family history and other complications of diabetes already developed in them. These were then compared with those of 90 normal healthy controls enrolled from general population using independent student’s t test and one way Anova test for scale variables and Chi square test for nominal variables.
Results: Both patients and controls were age and gender matched with mean age of 60 ± 8.9 years in patients and 59 ± 13.02 years in controls. Among 90 patients enrolled 51(56.7%) were males and 39 (43.3) were females. And among 90 controls 49 (54.4%) were males and 41(45.6%) were females. An inverse association was observed between inflammatory markers and physical activity with ap-value of 0.001. On the contrary a strong positive association was observed between inflammatory markers and family history and complications of diabetes with a p-value 0.001.
Conclusion: There is an inverse association of inflammatory markers with physical activity and a direct association of these with family history and complications of diabetes among patients of diabetic retinopathy.