THE EFFECT OF OLIVE-POMACE OIL ON DIFFERENT BLOOD PARAMETERS IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Effect of Olive-Pomace Oil on Blood Parameters in Rats
Keywords:Diabetes mellitus, Dyslipidemia, Hyperglycemia, Olive pomace oil
Objective: To determine the effects of olive-pomace oil on glycemic status and lipid profile in diabetes.
Study Design: Randomized controlled trial.
Place and Duration of Study: Department of Biochemistry, Army Medical College, Rawalpindi in collaboration with Centre for Research in Experimental and Applied Medicine, Army Medical College, Rawalpindi and National Institute of Health, Islamabad from March 2010 to June 2011.
Material and Methods: Seventy male albino rats of Sprague-Dawley strain were randomly divided into two groups of 35 rats each. Rats were rendered diabetic by injecting streptozotocin. Group 1 and group 2 were given normal rodent diet and olive pomace oil supplemented diet respectively for 6 weeks. At the end of the experiment fasting blood glucose and lipid profile were measured for comparison.
Results: There was significant increase in high density lipoprotein and significant decrease of blood glucose, total cholesterol and low density lipoprotein of group II rats when compared with group I (control).
Conclusion: Olive pomace oil can significantly improve fasting blood glucose and lipid profile in diabetic rats.